Evidence map›Paper›PMID 33808880›Full record

ArticleInternational journal of molecular sciences2021

Co-Incubation with PPARβ/δ Agonists and Antagonists Modeled Using Computational Chemistry: Effect on LPS Induced Inflammatory Markers in Pulmonary Artery.

Noelia Perez Diaz, Lisa A Lione, Victoria Hutter, Louise S Mackenzie

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. PPARs as Key Mediators in the Regulation of Metabolism and Inflammation.International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Noelia Perez DiazSchool of Life and Medical Sciences, University of Hertfordshire, Hatfield AL10 9AB, UK.ORCID 0000-0002-5410-9306
Lisa A LioneSchool of Life and Medical Sciences, University of Hertfordshire, Hatfield AL10 9AB, UK.
Victoria HutterSchool of Life and Medical Sciences, University of Hertfordshire, Hatfield AL10 9AB, UK.
Louise S MackenzieSchool of Life and Medical Sciences, University of Hertfordshire, Hatfield AL10 9AB, UK.
University of Hertfordshire · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peroxisome proliferator activated receptor beta/delta (PPARβ/δ) is a nuclear receptor ubiquitously expressed in cells, whose signaling controls inflammation. There are large discrepancies in understanding the complex role of PPARβ/δ in disease, having both anti- and pro-effects on inflammation. After ligand activation, PPARβ/δ regulates genes by two different mechanisms; induction and transrepression, the effects of which are difficult to differentiate directly. We studied the PPARβ/δ-regulation of lipopolysaccharide (LPS) induced inflammation (indicated by release of nitrite and IL-6) of rat pulmonary artery, using different combinations of agonists (GW0742 or L-165402) and antagonists (GSK3787 or GSK0660). LPS induced release of NO and IL-6 is not significantly reduced by incubation with PPARβ/δ ligands (either agonist or antagonist), however, co-incubation with an agonist and antagonist significantly reduces LPS-induced nitrite production and

Indexed as

AnimalsBenzamidesBinding SitesBiomarkersGene ExpressionInflammation MediatorsLigandsLipopolysaccharidesMaleMolecular ConformationMolecular Docking SimulationMolecular Dynamics SimulationNitric OxidePhenolsPPAR-betaPPAR delta(4-(((2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methyl-1,3-thiazol-5-yl)methyl)sulfanyl)-2-methylphenoxy)acetic acid4-chloro-N-(2-((5-trifluoromethyl-2-pyridyl)sulfonyl)ethyl)benzamideBenzamidesBiomarkersInflammation MediatorsLigandsLipopolysaccharidesNitric OxidePhenolsPPAR-betaPPAR deltaSulfhydryl CompoundsSulfonesThiazolesdockinggene transcriptionGSK3787GW0742inflammationlipopolysaccharide (LPS)lungmolecular dockingnuclear receptorPPARβ/δpulmonary artery

Identifiers

PMID33808880
PMCPMC8003823
OpenAlexW3138930417

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.