Evidence map›Paper›PMID 33808549›Full record

ReviewCancers2021

Resistance to Cell Death in Mucinous Colorectal Cancer-A Review.

Emer O'Connell, Ian S Reynolds, Deborah A McNamara, John P Burke, Jochen H M Prehn

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Article
  3. The Power of MUC2 in Mucinous Adenocarcinomas.Pathobiology : journal of immunopathology, molecular and cellular biology · 2026
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Bromelain and acetylcysteine (BromAcAmerican journal of cancer research · 2023
    Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Emer O'ConnellDepartment of Colorectal Surgery, Beaumont Hospital, Dublin 9, Ireland.
Ian S ReynoldsDepartment of Colorectal Surgery, Beaumont Hospital, Dublin 9, Ireland.ORCID 0000-0002-8790-2538
Deborah A McNamaraDepartment of Colorectal Surgery, Beaumont Hospital, Dublin 9, Ireland.
John P BurkeDepartment of Colorectal Surgery, Beaumont Hospital, Dublin 9, Ireland.
Jochen H M PrehnDepartment of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland.ORCID 0000-0003-3479-7794
Royal College of Surgeons in Ireland · IEBeaumont Hospital · IE

Funding

RCSI StAR MD 19437Royal College of Surgeons in Ireland 19437
6 · The paper itself

Abstract

Mucinous colorectal cancer (CRC) is estimated to occur in approximately 10-15% of CRC cases and is characterized by abundant extracellular mucin. Mucinous CRC is frequently associated with resistance to apoptosis. Inferior prognosis is observed in mucinous CRC, particularly in rectal cancer and metastatic cases. Mucins are heavily glycosylated secretory or transmembrane proteins that participate in protection of the colonic epithelium. MUC2 overexpression is a hallmark of mucinous CRCs. Mucinous CRC is associated with KRAS and BRAF mutation, microsatellite instability and the CpG island methylator phenotype. Mutations of the

Indexed as

apoptosischemo-resistancecolorectalmucin

Identifiers

PMID33808549
PMCPMC8003305
OpenAlexW3137597634

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.