ReviewInternational journal of molecular sciences2021
Cushing's Syndrome Effects on the Thyroid.
Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Ectopic ACTH Syndrome Caused by Pheochromocytoma: A Case Report and Systematic Review.Endocrine, metabolic & immune disorders drug targets · 2026Pooled it
- Thyroid hormone levels in patients with bipolar disorder: a systematic review and meta-analysis.BMC endocrine disorders · 2024Pooled it
- Thyroid function spectrum in Cushing's syndrome.BMC endocrine disorders · 2024Pooled it
- Human biomarker navigator.iMeta · 2026Review
- A retrospective study of severity-dependent HPG Axis suppression by glucocorticoids in Chinese women with Cushing syndrome.Frontiers in endocrinology · 2026Article
- Case Report: Reversible central hypothyroidism-like thyroid dysfunction revealing ACTH-independent cushing syndrome during pregnancy.Frontiers in medicine · 2026Article
- [Cushing's disease in a 15-year-old boy, manifesting in prepubertal age].Problemy endokrinologii · 2025Article
- Diagnosis and Management of Cushing's Syndrome During Pregnancy: Two Cases Report and Literature Review.Clinical case reports · 2025Article
- Genetics of ischemic stroke functional outcome.Journal of neurology · 2024Review
- [Primary Generalized Glucocorticoid Resistance: a case report].Problemy endokrinologii · 2024Article
- Clinical and therapeutic outcomes of pediatric pituitary adenomas: a single pituitary center experience.Endocrine · 2024Article
- Association of thyroid autoimmunity with extra-thyroid diseases and the risk of mortality among adults: evidence from the NHANES.Frontiers in endocrinology · 2024Article
- Review
- Osteoporosis as the First Sign of Cushing's Disease in a Thin 16-Year-Old Boy-A Case Report.Journal of clinical medicine · 2023Article
- A Causality between Thyroid Function and Bone Mineral Density in Childhood: Abnormal Thyrotropin May Be Another Pediatric Predictor of Bone Fragility.Metabolites · 2023Article
- Case report: Central-pituitary hypothyroidism concurrent with hyperadrenocorticism without pituitary macroadenoma in a Miniature Schnauzer dog.Frontiers in veterinary science · 2023Article
- Thyroid-Stimulating Hormone as a Biomarker for Stress After Thyroid Surgery: A Prospective Cohort Study.Medical science monitor : international medical journal of experimental and clinical research · 2022Article
- Cortisol and Phosphate Homeostasis: Cushing's Syndrome Is Associated With Reversible Hypophosphatemia.Frontiers in endocrinology · 2021Article
- Real or Not Real? An Elevated TSH.Journal of investigative medicine high impact case reportsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The most known effects of endogenous Cushing's syndrome are the phenotypic changes and metabolic consequences. However, hypercortisolism can exert important effects on other endocrine axes. The hypothalamus-pituitary-thyroid axis activity can be impaired by the inappropriate cortisol secretion, which determinates the clinical and biochemical features of the "central hypothyroidism". These findings have been confirmed by several clinical studies, which also showed that the cure of hypercortisolism can determine the recovery of normal hypothalamus-pituitary-thyroid axis activity. During active Cushing's syndrome, the "immunological tolerance" guaranteed by the hypercortisolism can mask, in predisposed patients, the development of autoimmune thyroid diseases, which increases in prevalence after the resolution of hypercortisolism. However, the immunological mechanism is not the only factor that contributes to this phenomenon, which probably includes also deiodinase-impaired activity. Cushing's syndrome can also have an indirect impact on thyroid function, considering that some drugs used for the medical control of hypercortisolism are associated with alterations in the thyroid function test. These considerations suggest the utility to check the thyroid function in Cushing's syndrome patients, both during the active disease and after its remission.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.