Evidence map›Paper›PMID 33808480›Full record

ArticleNutrients2021

Inhibitory Effects of Breast Milk-Derived

Haiyan Xu, Keizo Hiraishi, Lin-Hai Kurahara, Yuko Nakano-Narusawa, Xiaodong Li, Yaopeng Hu, Yoko Matsuda, Heping Zhang, Katsuya Hirano

Abstract read
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. Article
  2. The role of gut microbiota and its metabolites in preventing oncogenesis.Frontiers in cell and developmental biology · 2026
    Review
  3. Review
  4. Nutrients · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Evaluation ofFrontiers in veterinary science · 2025
    Article
  9. Human breast milk and its impact on inflammatory bowel disease.Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2025
    Review
  10. Review
  11. Article
  12. Article
  13. Colorectal cancer and microbiota: systematic review.Przeglad gastroenterologiczny · 2024
    Review
  14. ProbioticsmSystems · 2023
    Article
  15. Article
  16. Molecules (Basel, Switzerland) · 2023
    Article
  17. Bacterial-Mediated Tumor Therapy: Old Treatment in a New Context.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Haiyan XuKey Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot 010018, China.
Keizo HiraishiDepartment of Cardiovascular Physiology, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan.
Lin-Hai KuraharaDepartment of Cardiovascular Physiology, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan.
Yuko Nakano-NarusawaOncology Pathology, Department of Pathology and Host-Defence, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan.
Xiaodong LiDepartment of Cardiovascular Physiology, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan.
Yaopeng HuDepartment of Physiology, Faculty of Medicine, Fukuoka University, Fukuoka 814-0180, Japan.
Yoko MatsudaOncology Pathology, Department of Pathology and Host-Defence, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan.ORCID 0000-0002-3235-655X
Heping ZhangKey Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot 010018, China.
Katsuya HiranoDepartment of Cardiovascular Physiology, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan.ORCID 0000-0003-0164-1283

Funding

Asia-centered International Joint Research Promotion Fund of Kagawa University Research Pro-motion Program 2020Fukuoka University 196001
6 · The paper itself

Abstract

Chronic inflammation is a risk factor for colorectal cancer, and inflammatory cytokines secreted from inflammatory cells and active oxygen facilitate tumorigenesis. Intestinal bacteria are thought to regulate tumorigenesis. The longer the breastfeeding period, the lower is the risk of inflammatory bowel disease. Here, we investigated preventive effects of the probiotic

Indexed as

Gastrointestinal MicrobiomeCarcinogenesisColitisColonic NeoplasmsDextran SulfateHumansInflammationLacticaseibacillus rhamnosusMaleMilk, HumanNeoplasms, ExperimentalDextran Sulfatecolitis-associated tumorigenesisinflammatory bowel diseaseLactobacillus rhamnosus M9probiotic

Identifiers

PMID33808480
PMCPMC8065529

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.