ArticlePathogens (Basel, Switzerland)2021
Characterization of Ocular Surface Microbial Profiles Revealed Discrepancies between Conjunctival and Corneal Microbiota.
Article in Pathogens (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- The bovine ocular microbiome: a multi-approach study of composition and antimicrobial activity.Animal microbiome · 2026Article
- The Ocular Surface Microbiome in Homeostasis and Dysbiosis.Microorganisms · 2025Review
- Review
- Sequencing the ocular surface microbiome: a review of methodological practices and considerations.Frontiers in ophthalmology · 2025Review
- Characterization of Vitreous Microbiota Dysbiosis Associated with Proliferative Diabetic Retinopathy.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Effects of preoperative topical levofloxacin on conjunctival microbiome in patients undergoing intravitreal injections.PloS one · 2025Article
- A New Approach to Evaluate the Bactericidal Activity of Different Antiseptic Ophthalmic Preparations Used as Surgical Prophylaxis.Antibiotics (Basel, Switzerland) · 2024Article
- Next-Generation Sequencing of the Human Aqueous Humour Microbiome.International journal of molecular sciences · 2024Article
- Living with your biome: how the bacterial microbiome impacts ocular surface health and disease.Expert review of ophthalmology · 2024Article
- Longitudinal Changes of Ocular Surface Microbiome in Patients Undergoing Hemopoietic Stem Cell Transplant (HSCT).Journal of clinical medicine · 2023Article
- Molecular Characterization of Bacterial Agents Causing External Ocular Infections Isolates of Patients in a Third Level Hospital.Pathogens (Basel, Switzerland) · 2023Article
- Whole-body microbiota of newborn calves and their response to prenatal vitamin and mineral supplementation.Frontiers in microbiology · 2023Article
- Alterations of the bacterial ocular surface microbiome are found in both eyes of horses with unilateral ulcerative keratitis.PloS one · 2023Article
- Characterization and Comparison of Ocular Surface Microbiome in Newborns.Microorganisms · 2022Article
- Microbiome in Immune-Mediated Uveitis.International journal of molecular sciences · 2022Review
- Shotgun metagenomic sequencing analysis of ocular surface microbiome in Singapore residents with mild dry eye.Frontiers in medicine · 2022Article
- Editorial: Next-generation sequencing in ophthalmology: The microbiome in ocular health and disease.Frontiers in cellular and infection microbiology · 2022Article
- Profiling of the Conjunctival Bacterial Microbiota Reveals the Feasibility of Utilizing a Microbiome-Based Machine Learning Model to Differentially Diagnose Microbial Keratitis and the Core Components of the Conjunctival Bacterial Interaction Network.Frontiers in cellular and infection microbiology · 2022Article
- The Impact of Human Microbiotas in Hematopoietic Stem Cell and Organ Transplantation.Frontiers in immunology · 2022Review
- Conjunctival Sac Microbiome in Infectious Conjunctivitis.Microorganisms · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
The ocular microbiome composition has only been partially characterized. Here, we used RNA-sequencing (RNA-Seq) data to assess microbial diversity in human corneal tissue. Additionally, conjunctival swab samples were examined to characterize ocular surface microbiota. Short RNA-Seq reads, obtained from a previous transcriptome study of 50 corneal tissues, were mapped to the human reference genome GRCh38 to remove sequences of human origin. The unmapped reads were then used for taxonomic classification by comparing them with known bacterial, archaeal, and viral sequences from public databases. The components of microbial communities were identified and characterized using both conventional microbiology and polymerase chain reaction (PCR) techniques in 36 conjunctival swabs. The majority of ocular samples examined by conventional and molecular techniques showed very similar microbial taxonomic profiles, with most of the microorganisms being classified into
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.