Evidence map›Paper›PMID 33808466›Full record

ArticleInternational journal of environmental research and public health2021

Abbreviated MRI Protocol for the Assessment of Ablated Area in HCC Patients.

Vincenza Granata, Roberta Grassi, Roberta Fusco, Sergio Venanzio Setola, Andrea Belli, Mauro Piccirillo, Silvia Pradella, Marzia Giordano, Salvatore Cappabianca, Luca Brunese and 3 more

Open access · goldAbstract read
In one paragraph

Article in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.2field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 23 citations in OpenAlex.

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  9. Immunotherapy Assessment: A New Paradigm for Radiologists.Diagnostics (Basel, Switzerland) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Vincenza GranataRadiology Division, "Istituto Nazionale Tumori IRCCS Fondazione Pascale-IRCCS di Napoli", 80131 Naples, Italy.
Roberta GrassiDivision of Radiology, University of Campania Luigi Vanvitelli, 80127 Naples, Italy.
Roberta FuscoRadiology Division, "Istituto Nazionale Tumori IRCCS Fondazione Pascale-IRCCS di Napoli", 80131 Naples, Italy.ORCID 0000-0002-0469-9969
Sergio Venanzio SetolaRadiology Division, "Istituto Nazionale Tumori IRCCS Fondazione Pascale-IRCCS di Napoli", 80131 Naples, Italy.
Andrea BelliHepatobiliary Surgical Oncology Division, "Istituto Nazionale Tumori IRCCS Fondazione Pascale-IRCCS di Napoli", 80131 Naples, Italy.
Mauro PiccirilloHepatobiliary Surgical Oncology Division, "Istituto Nazionale Tumori IRCCS Fondazione Pascale-IRCCS di Napoli", 80131 Naples, Italy.
Silvia PradellaDivision of Radiology, "Azienda Ospedaliera Universitaria Careggi", 50139 Florence, Italy.
Marzia GiordanoDivision of Radiology, University of Campania Luigi Vanvitelli, 80127 Naples, Italy.
Salvatore CappabiancaDivision of Radiology, University of Campania Luigi Vanvitelli, 80127 Naples, Italy.
Luca BruneseRadiology Division, Università degli Studi del Molise, Via Francesco De Sanctis, 86100 Campobasso, Italy.
Roberto GrassiDivision of Radiology, University of Campania Luigi Vanvitelli, 80127 Naples, Italy.
Antonella PetrilloRadiology Division, "Istituto Nazionale Tumori IRCCS Fondazione Pascale-IRCCS di Napoli", 80131 Naples, Italy.ORCID 0000-0003-2465-5370
Francesco IzzoHepatobiliary Surgical Oncology Division, "Istituto Nazionale Tumori IRCCS Fondazione Pascale-IRCCS di Napoli", 80131 Naples, Italy.ORCID 0000-0003-3093-5408
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" · ITUniversity of Campania "Luigi Vanvitelli" · ITAzienda Ospedaliero-Universitaria Careggi · ITUniversity of Molise · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLiver Imaging Reporting and Data Systems (LI-RADS) Treatment Response Algorithm (TRA) was created to provide a standardized assessment of hepatocellular carcinoma (HCC) following loco regional therapy. The aim of this study was to compare sensitivity of standard MRI protocol versus abbreviated protocol (only T1-Weigthed fat suppressed (FS) sequences pre- and post-contrast phase) in the detection of ablated area according to LI-RADS Treatment Response (LR-TR) categories.

methodsFrom January 2015 to June 2020, we selected 64 patients with HCC, who underwent Radiofrequency ablation (RFA) or Microwave ablation (MWA) treatment. According to inclusion criteria, 136 pathologically proven treated HCC (median 2, range 1-3 per patient; mean size 20.0 mm; range 15-30 mm) in 58 patients (26 women, 32 men; median age, 74 years; range, 62-83 years) comprised our study population. For each ablated area, abbreviated protocol, and standard Magnetic Resonance Imaging (MRI) studies were independently and blindly assessed in random order within and between three expert radiologists. Each radiologist assessed the ablated area by using the following categories: "LR-TR Non-viable" = 1; "LR-TR Equivocal" = 2 and "LR-TR Viable" = 0.

resultsAccording to the concordance between MRI and Contrast enhancement ultrasound (CEUS) among 136 treated HCCs, 115 lesions were assessed as non-viable or totally ablate and 21 as viable or partially ablate. The accuracy for standard MRI protocol and abbreviated MRI protocol for predicting pathologic tumor viability of a consensus reading was 98.6% (sensitivity = 100%; specificity = 98.3%; positive predictive value = 91.3% and negative predictive value = 100%). No differences were found in sensitivity or specificity between standard MRI LR-TR viable and abbreviated MRI LR-TR viable categories (

conclusionThe abbreviated dynamic protocol showed similar diagnostic accuracy to conventional MRI study in the assessment of treated HCCs, with a reduction of the acquisition study time of 30% respect to conventional MRI.

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsAgedContrast MediaFemaleHumansMagnetic Resonance ImagingMaleRetrospective StudiesContrast Mediaablation treatmentcontrast enhancement MRIDWIHCCmagnetic resonance imaging

Identifiers

PMID33808466
PMCPMC8037601
OpenAlexW3152280602

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.