Evidence map›Paper›PMID 33808444›Full record

ArticleMolecules (Basel, Switzerland)2021

Synthesis and Rational Design of New Appended 1,2,3-Triazole-uracil Ensembles as Promising Anti-Tumor Agents via In Silico VEGFR-2 Transferase Inhibition.

Nadipolla Naresh Reddy, Sung-Jen Hung, Merugu Kumara Swamy, Ananthula Sanjeev, Vankadari Srinivasa Rao, Rondla Rohini, Atcha Krishnam Raju, Kuthati Bhaskar, Anren Hu, Puchakayala Muralidhar Reddy

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
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  5. New Oxazolo[5,4-International journal of molecular sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Nadipolla Naresh ReddyDepartment of Chemistry, Osmania University, Hyderabad, Telangana 500007, India.
Sung-Jen HungDepartment of Dermatology, Buddhist Tzu-Chi General Hospital, Hualien 97002, Taiwan.
Merugu Kumara SwamyDepartment of Chemistry, Osmania University, Hyderabad, Telangana 500007, India.
Ananthula SanjeevDepartment of Chemistry, Osmania University, Hyderabad, Telangana 500007, India.
Vankadari Srinivasa RaoDepartment of Chemistry, Osmania University, Hyderabad, Telangana 500007, India.
Rondla RohiniDepartment of Chemistry, Osmania University, Hyderabad, Telangana 500007, India.
Atcha Krishnam RajuDepartment of Chemistry, Nizam College, Osmania University, Hyderabad 500001, India.
Kuthati BhaskarDepartment of Chemistry, Osmania University, Hyderabad, Telangana 500007, India.
Anren HuInstitute of Medical Sciences, Tzu-Chi University, Hualien 97002, Taiwan.
Puchakayala Muralidhar ReddyDepartment of Chemistry, Osmania University, Hyderabad, Telangana 500007, India.
Osmania University · INTzu Chi University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Angiogenesis inhibition is a key step towards the designing of new chemotherapeutic agents. In a view to preparing new molecular entities for cancer treatment, eighteen 1,2,3-triazole-uracil ensembles

Indexed as

Antineoplastic AgentsProtein Kinase InhibitorsTriazolesUracilVascular Endothelial Growth Factor Receptor-2AnimalsCell ProliferationDose-Response Relationship, DrugDrug DesignDrug Screening Assays, AntitumorHeLa CellsHumansMiceMolecular StructureNIH 3T3 CellsProtein BindingAntineoplastic AgentsProtein Kinase InhibitorsTriazolesUracilVascular Endothelial Growth Factor Receptor-21,2,3-triazole-uracilanti-cancer agentsdrug designin silico dockingMTT assayVEGFR-2

Identifiers

PMID33808444
PMCPMC8037033
OpenAlexW3150929668

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.