Evidence map›Paper›PMID 33808361›Full record

ReviewPharmaceutics2021

Recent Advances in Biomedical, Therapeutic and Pharmaceutical Applications of Microbial Surfactants.

Chiara Ceresa, Letizia Fracchia, Emanuele Fedeli, Chiara Porta, Ibrahim M Banat

Open access · goldAbstract readReview
In one paragraph

Review in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Biotechnological Potential of RhizosphericInternational journal of molecular sciences · 2026
    Article
  5. Review
  6. Review
  7. A Glycolipid-Like Biosurfactant Molecule Derived From anInternational journal of microbiology · 2026
    Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Exploring the biofilm inhibitory potential of Candida sp. UFSJ7A glycolipid on siliconized latex catheters.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024
    Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Chiara CeresaDepartment of Pharmaceutical Sciences, Università del Piemonte Orientale "A. Avogadro", 28100 Novara, Italy.
Letizia FracchiaDepartment of Pharmaceutical Sciences, Università del Piemonte Orientale "A. Avogadro", 28100 Novara, Italy.ORCID 0000-0003-3505-1919
Emanuele FedeliDepartment of Pharmaceutical Sciences, Università del Piemonte Orientale "A. Avogadro", 28100 Novara, Italy.
Chiara PortaDepartment of Pharmaceutical Sciences, Università del Piemonte Orientale "A. Avogadro", 28100 Novara, Italy.ORCID 0000-0002-7183-5561
Ibrahim M BanatPharmaceutical Science Research Group, Biomedical Science Research Institute, Ulster University, Coleraine, Northern Ireland BT52 1SA, UK.ORCID 0000-0001-8964-2840
Università degli Studi del Piemonte Orientale “Amedeo Avogadro” · ITUniversity of Ulster · GB

Funding

Università degli Studi del Piemonte Orientale "A. Avogadro" FAR project 2019
6 · The paper itself

Abstract

The spread of antimicrobial-resistant pathogens typically existing in biofilm formation and the recent COVID-19 pandemic, although unrelated phenomena, have demonstrated the urgent need for methods to combat such increasing threats. New avenues of research for natural molecules with desirable properties to alleviate this situation have, therefore, been expanding. Biosurfactants comprise a group of unique and varied amphiphilic molecules of microbial origin capable of interacting with lipidic membranes/components of microorganisms and altering their physicochemical properties. These features have encouraged closer investigations of these microbial metabolites as new pharmaceutics with potential applications in clinical, hygiene and therapeutic fields. Mounting evidence has indicated that biosurfactants have antimicrobial, antibiofilm, antiviral, immunomodulatory and antiproliferative activities that are exploitable in new anticancer treatments and wound healing applications. Some biosurfactants have already been approved for use in clinical, food and environmental fields, while others are currently under investigation and development as antimicrobials or adjuvants to antibiotics for microbial suppression and biofilm eradication strategies. Moreover, due to the COVID-19 pandemic, biosurfactants are now being explored as an alternative to current products or procedures for effective cleaning and handwash formulations, antiviral plastic and fabric surface coating agents for shields and masks. In addition, biosurfactants have shown promise as drug delivery systems and in the medicinal relief of symptoms associated with SARS-CoV-2 acute respiratory distress syndrome.

Indexed as

antiadhesive/antibiofilm agentsanticancer agentsantimicrobialsantiviral activitybiosurfactantsimmuno-modulation activitywound-healing promoters

Identifiers

PMID33808361
PMCPMC8067001
OpenAlexW3151431459

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.