ReviewJournal of clinical medicine2021
What Is the Quality of Life in Patients Treated with Levothyroxine for Hypothyroidism and How Are We Measuring It? A Critical, Narrative Review.
Review in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 21 citations in OpenAlex.
- Trial
- Early effects of LT3 + LT4 combination therapy on quality of life in hypothyroid patients: a randomized, double-blind, parallel-group comparison trial.BMC endocrine disorders · 2025Trial
- The effect of synbiotic supplementation on hypothyroidism: A randomized double-blind placebo controlled clinical trial.PloS one · 2023Trial
- Investigating the relationship between thyroid replacement therapy goals status and quality of life in patients with primary hypothyroidism.Endocrine · 2026Article
- Psychometric properties of the thyroid-specific quality of life questionnaire ThyPRO-39 in patients with hypothyroidism.Journal of family medicine and primary care · 2026Article
- Longitudinal relationships of malnutrition risk, sleep disturbance, and fear of cancer recurrence in thyroid cancer patients: a cross-lagged panel model.Frontiers in nutrition · 2026Article
- Neurodevelopmental Disorders, Cognitive Function, and Quality of Life in Children with Congenital Hypothyroidism in a Portuguese PopulationJournal of clinical research in pediatric endocrinology · 2025Article
- Self-Management and Support Needs of Patients Experiencing Persistent Symptoms Consistent With Hypothyroidism: A Qualitative Study.Journal of patient-centered research and reviews · 2025Article
- Impaired autonomic function and somatosensory disturbance in patients with treated autoimmune thyroiditis.Scientific reports · 2024Article
- Treatment of Hypothyroidism and Stress Using Neuro-Emotional Technique (NET): A Case Study.Cureus · 2024Article
- The Effect of Some Micronutrients Multi-Supplementation on Thyroid Function, Metabolic Features and Quality of Life in Patients Treating With Levothyroxine and Vitamin D: A Double-blind, Randomized Controlled Trial.Medical journal of the Islamic Republic of Iran · 2024Article
- Severity of Fatigue and Its Relationship with TSH before and after Levothyroxine Replacement Therapy in Patients with Primary Hypothyroidism.Biomedicines · 2023Article
- Practical Guidelines for Diagnosing and Treating Thyroid Disease Based on the WOMED Metabolic Model of Disease Focusing on Glycolysis and Coenzyme QDiagnostics (Basel, Switzerland) · 2022Article
- Evaluating health outcomes in the treatment of hypothyroidism.Frontiers in endocrinology · 2022Review
- Relatively Lower FT3 Levels Are Associated with Impaired Quality of Life in Levothyroxine-Treated Patients with Hashimoto Thyroiditis.International journal of endocrinology · 2022Article
- Methimazole plus levothyroxine for treating hyperthyroidism in children: a systematic review and meta-analysis.Translational pediatrics · 2022Article
- Health-related quality of life and its association with the symptom score and the thyroid function status of patients with primary hypothyroidism on replacement therapy.Journal of family & community medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Thyroid hormone replacement therapy (THRT, generally using oral levothyroxine (LT4)) is a safe, effective means of treating hypothyroidism. However, a proportion of LT4-treated patients with biochemically normal thyroid function tests complain of persistent symptoms that impact their health-related quality of life (QoL). The objectives of this critical, narrative review of the literature were to identify studies of QoL in LT4-treated patients with hypothyroidism, examine the instruments used to measure QoL, determine whether normal QoL is restored by THRT, and identify factors associated with QoL. The PubMed database was searched from 1 January 2000 to 31 December 2020. A total of 809 publications were screened, 129 full-text articles were retrieved, and 58 were analyzed. The studies of overt hypothyroidism evidenced an improvement in psychological and emotional well-being after three to six months of THRT with LT4, although contrasting results were found for patients with subclinical hypothyroidism. Combination treatment with LT4 and liothyronine was not generally associated with better QoL. In hypothyroidism, QoL appears to be influenced by a number of physiological, behavioral, cognitive and/or lifestyle factors that are not strictly related to thyroid hormone levels.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.