ArticleInternational journal of environmental research and public health2021
Frailty Status and Polypharmacy Predict All-Cause Mortality in Community Dwelling Older Adults in Europe.
Article in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Validated frailty measures using electronic primary care records: a review of diagnostic test accuracy.Age and ageing · 2023Pooled it
- Pre-Frailty and Frailty in Dialysis and Pre-Dialysis Patients: A Systematic Review of Clinical and Biochemical Markers.International journal of environmental research and public health · 2021Pooled it
- Trial
- Epigenetic aging markers in the association between frailty and mortality among U.S. adults.BMC medicine · 2026Article
- The association between polypharmacy and mortality in patients with heart failure: Results from the PULSE dataset.ESC heart failure · 2025Observational
- Medication Use by Older Adults with Frailty: A Scoping Review.Pharmacy (Basel, Switzerland) · 2025Review
- Prevalence and Determinants of Frailty in Community-Dwelling Iranian Older Adults: A Cross-Sectional Study.Health science reports · 2025Article
- Geriatric Assessment as an Important Tool for Post-Hip Surgery Prognosis in Seniors.Nursing reports (Pavia, Italy) · 2025Article
- Frail older people ageing in place alone and their perception of the built environment in rural and urban sites: a mixed-methods study.BMC geriatrics · 2025Article
- FRAILSURVEY-an mHealth App for Self-Assessment of Frailty Based on the Portuguese Version of the Groningen Frailty Indicator: Validation and Reliability Study.JMIR formative research · 2025Article
- Integrated approach to reducing polypharmacy in older people: exploring the role of oxidative stress and antioxidant potential therapy.Redox report : communications in free radical research · 2024Review
- Assessing Cardiovascular Risk in Geriatric Patients Without Atherosclerotic Cardiovascular Disease.Journal of clinical medicine · 2024Article
- Identifying and Estimating Frailty Phenotypes by Vocal Biomarkers: Cross-Sectional Study.Journal of medical Internet research · 2024Article
- General practitioners' views on inappropriate prescribing for older patients: a qualitative study through focus groups.BMC geriatrics · 2024Article
- What is the association of polypharmacy with frailty in heart failure? A systematic review and meta-analysis.Journal of frailty, sarcopenia and falls · 2024Review
- Integrating frailty interventions into existing care models: a comprehensive approach to enhancing patient outcomes in chronic disease management.Frontiers in public health · 2024Review
- Frailty in Kingdom of Saudi Arabia-Prevalence and Management, Where Are We?Healthcare (Basel, Switzerland) · 2023Article
- Factors related to polypharmacy and hyper-polypharmacy for the elderly: A nationwide cohort study using National Health Insurance data in South Korea.Clinical and translational science · 2023Observational
- Frailty modifies the effect of polypharmacy and multimorbidity on the risk of death among nursing home residents: Results from the SHELTER study.Frontiers in medicine · 2023Article
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
European population ageing is associated with frailty, a complex geriatric syndrome, and polypharmacy, both resulting in adverse health outcomes. In this study we aimed to evaluate the impact of frailty and polypharmacy, on mortality rates, within 30 months, using a cohort of SHARE participants aged 65 years old or more. Frailty was assessed using a version of Fried's phenotype criteria operationalized to SHARE while polypharmacy was defined as taking five or more drugs per day. We found a prevalence of 40.4% non-frail, 47.3% pre-frail and 12.3% frail participants. Moreover, a prevalence of polypharmacy of 31.3% was observed, being 3 three times more prevalent in frail individuals and two times in pre-frail individuals, when compared with non-frail. Individuals with both conditions had shown higher mortality rates. Comparing with non-polymedicated non-frail individuals all the other conditions are more prone to die within 30 months. Polymedicated older and male participants exhibited also higher mortality rates. This work shows polypharmacy and frailty to be associated with a higher risk of all-cause of mortality and highlights the need to decrease 'unnecessary' polypharmacy to reduce drug-related issues and also the need to assess frailty early to prevent avoidable adverse outcomes.
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