Evidence map›Paper›PMID 33808251›Full record

ArticleNutrients2021

Peripancreatic Adipose Tissue Remodeling and Inflammation during High Fat Intake of Palm Oils or Lard in Rats.

Jonas Laget, Youzan Ferdinand Djohan, Laura Jeanson, Karen Muyor, Eric Badia, Jean Paul Cristol, Charles Coudray, Christine Feillet-Coudray, Claire Vigor, Camille Oger and 5 more

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Jonas LagetRD-Néphrologie, 34090 Montpellier, France.ORCID 0000-0002-9095-7409
Youzan Ferdinand DjohanPHYMEDEXP, INSERM, CNRS, Université de Montpellier, 34090 Montpellier, France.
Laura JeansonBC2M, UR-UM 101, UFR Pharmacie, Université de Montpellier, 34090 Montpellier, France.
Karen MuyorRD-Néphrologie, 34090 Montpellier, France.
Eric BadiaPHYMEDEXP, INSERM, CNRS, Université de Montpellier, 34090 Montpellier, France.
Jean Paul CristolPHYMEDEXP, INSERM, CNRS, Université de Montpellier, 34090 Montpellier, France.
Charles CoudrayDMEM, EMN, UMR 866, INRAe, Université de Montpellier, 34090 Montpellier, France.ORCID 0000-0003-2680-7796
Christine Feillet-CoudrayDMEM, EMN, UMR 866, INRAe, Université de Montpellier, 34090 Montpellier, France.ORCID 0000-0001-8420-2811
Claire VigorIBMM, UMR 5247, CNRS, Université de Montpellier, ENSCM, 34090 Montpellier, France.ORCID 0000-0002-1569-0425
Camille OgerIBMM, UMR 5247, CNRS, Université de Montpellier, ENSCM, 34090 Montpellier, France.ORCID 0000-0002-5177-5792
Jean-Marie GalanoIBMM, UMR 5247, CNRS, Université de Montpellier, ENSCM, 34090 Montpellier, France.
Thierry DurandIBMM, UMR 5247, CNRS, Université de Montpellier, ENSCM, 34090 Montpellier, France.
Anne-Dominique LajoixBC2M, UR-UM 101, UFR Pharmacie, Université de Montpellier, 34090 Montpellier, France.ORCID 0000-0002-5912-5233
Nathalie GayrardRD-Néphrologie, 34090 Montpellier, France.ORCID 0000-0001-8283-8429
Bernard JoverPHYMEDEXP, INSERM, CNRS, Université de Montpellier, 34090 Montpellier, France.ORCID 0000-0001-5826-5755
Université de Montpellier · FRCentre National de la Recherche Scientifique · FRÉcole Nationale Supérieure de Chimie de Montpellier · FR

Funding

Région Occitanie Pyrénées-Méditerranée 18022518
6 · The paper itself

Abstract

Excessive fat consumption leads to the development of ectopic adipose tissues, affecting the organs they surround. Peripancreatic adipose tissue is implicated in glucose homeostasis regulation and can be impaired in obesity. High palm oil consumption's effects on health are still debated. We hypothesised that crude and refined palm oil high-fat feeding may have contrasting effects on peripancreatic adipocyte hypertrophy, inflammation and lipid oxidation compound production in obese rats. In Wistar rats, morphological changes, inflammation and isoprostanoid production following oxidative stress were assessed in peripancreatic adipose tissue after 12 weeks of diets enriched in crude or refined palm oil or lard (56% energy from fat in each case) versus a standard chow diet (11% energy from fat). Epididymal white and periaortic brown adipose tissues were also included in the study. A refined palm oil diet disturbed glucose homeostasis and promoted lipid deposition in periaortic locations, as well as adipocyte hypertrophy, macrophage infiltration and isoprostanoid (5-F

Indexed as

Adipose TissueAnimalsBlood GlucoseBody WeightDietary FatsDiet, High-FatGlucoseInflammationLipidsMacrophagesMalePalm OilRatsRats, WistarBlood GlucoseDietary FatsGlucoselardLipidsPalm Oiladipose tissuehigh fat intakeinflammationlipid oxidationpalm oil

Identifiers

PMID33808251
PMCPMC8065769
OpenAlexW3144453621

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.