Evidence map›Paper›PMID 33808062›Full record

ReviewInternational journal of molecular sciences2021

MicroRNA Interference in Hepatic Host-Pathogen Interactions.

Asahiro Morishita, Kyoko Oura, Tomoko Tadokoro, Koji Fujita, Joji Tani, Tsutomu Masaki

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Editorial of Special Issue "Non-Coding RNAs in Pathogen-Host Interaction".International journal of molecular sciences · 2021
    Article
  11. Diagnosis and Therapeutic Management of Liver Fibrosis by MicroRNA.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Asahiro MorishitaDepartment of Gastroenterology and Neurology, Kagawa University School of Medicine, Kagawa 761-0793, Japan.ORCID 0000-0002-0760-3045
Kyoko OuraDepartment of Gastroenterology and Neurology, Kagawa University School of Medicine, Kagawa 761-0793, Japan.ORCID 0000-0002-9531-7240
Tomoko TadokoroDepartment of Gastroenterology and Neurology, Kagawa University School of Medicine, Kagawa 761-0793, Japan.
Koji FujitaDepartment of Gastroenterology and Neurology, Kagawa University School of Medicine, Kagawa 761-0793, Japan.ORCID 0000-0001-9390-7565
Joji TaniDepartment of Gastroenterology and Neurology, Kagawa University School of Medicine, Kagawa 761-0793, Japan.ORCID 0000-0001-8801-2505
Tsutomu MasakiDepartment of Gastroenterology and Neurology, Kagawa University School of Medicine, Kagawa 761-0793, Japan.
Kagawa University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The liver is well recognized as a non-immunological visceral organ that is involved in various metabolic activities, nutrient storage, and detoxification. Recently, many studies have demonstrated that resident immune cells in the liver drive various immunological reactions by means of several molecular modulators. Understanding the mechanistic details of interactions between hepatic host immune cells, including Kupffer cells and lymphocytes, and various hepatic pathogens, especially viruses, bacteria, and parasites, is necessary. MicroRNAs (miRNAs), over 2600 of which have been discovered, are small, endogenous, interfering, noncoding RNAs that are predicted to regulate more than 15,000 genes by degrading specific messenger RNAs. Several recent studies have demonstrated that some miRNAs are associated with the immune response to pathogens in the liver. However, the details of the underlying mechanisms of miRNA interference in hepatic host-pathogen interactions still remain elusive. In this review, we summarize the relationship between the immunological interactions of various pathogens and hepatic resident immune cells, as well as the role of miRNAs in the maintenance of liver immunity against pathogens.

Indexed as

AnimalsGene Expression RegulationHepatitisHepatitis VirusesHost-Pathogen InteractionsHumansLiverLiver AbscessMicroRNAsPelvic Inflammatory DiseasePeritonitisMicroRNAsdiagnostic biomarkerepigenetic changeshost–pathogen interactionimmune cellsliver immunitymicroRNApathogenRNA interference

Identifiers

PMID33808062
PMCPMC8036276
OpenAlexW3145534871

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.