Evidence map›Paper›PMID 33808053›Full record

ArticleViruses2021

Increasing Capacity to Detect Clusters of Rapid HIV Transmission in Varied Populations-United States.

Alexandra M Oster, Nivedha Panneer, Sheryl B Lyss, R Paul McClung, Meg Watson, Neeraja Saduvala, M Cheryl Bañez Ocfemia, Laurie Linley, William M Switzer, Joel O Wertheim and 3 more

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
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  6. Molecular HIV Surveillance: Beyond Cluster Detection and Response.AIDS research and human retroviruses · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Alexandra M OsterCenters for Disease Control and Prevention, Atlanta, GA 30329, USA.
Nivedha PanneerCenters for Disease Control and Prevention, Atlanta, GA 30329, USA.
Sheryl B LyssCenters for Disease Control and Prevention, Atlanta, GA 30329, USA.
R Paul McClungCenters for Disease Control and Prevention, Atlanta, GA 30329, USA.
Meg WatsonCenters for Disease Control and Prevention, Atlanta, GA 30329, USA.
Neeraja SaduvalaICF International, Atlanta, GA 30329, USA.
M Cheryl Bañez OcfemiaCenters for Disease Control and Prevention, Atlanta, GA 30329, USA.
Laurie LinleyCenters for Disease Control and Prevention, Atlanta, GA 30329, USA.
William M SwitzerCenters for Disease Control and Prevention, Atlanta, GA 30329, USA.ORCID 0000-0003-4591-8731
Joel O WertheimDepartment of Medicine, University of California San Diego, San Diego, CA 92093, USA.
Ellsworth CampbellCenters for Disease Control and Prevention, Atlanta, GA 30329, USA.ORCID 0000-0002-9535-4420
Angela L HernandezCenters for Disease Control and Prevention, Atlanta, GA 30329, USA.
Anne Marie FranceCenters for Disease Control and Prevention, Atlanta, GA 30329, USA.
Centers for Disease Control and Prevention · USICF International (United States) · USUniversity of California San Diego · US

Funding

Automation and Evaluation of Real-Time Transmission Network-Based HIV Prevention Services in New York CityR01AI135992 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WERTHEIM, JOEL OKRENT · 2018 to 2022
$3.6M
NIAID NIH HHS R01 AI135992
6 · The paper itself

Abstract

Molecular cluster detection analyzes HIV sequences to identify rapid HIV transmission and inform public health responses. We describe changes in the capability to detect molecular clusters and in geographic variation in transmission dynamics. We examined the reporting completeness of HIV-1 polymerase sequences in quarterly National HIV Surveillance System datasets from December 2015 to December 2019. Priority clusters were identified quarterly. To understand populations recently affected by rapid transmission, we described the transmission risk and race/ethnicity of people in clusters first detected in 2018-2019. During December 2015 to December 2019, national sequence completeness increased from 26% to 45%. Of the 1212 people in the 136 clusters first detected in 2018-2019, 69% were men who have sex with men (MSM) and 11% were people who inject drugs (PWID). State-by-state analysis showed substantial variation in transmission risk and racial/ethnic groups in clusters of rapid transmission. HIV sequence reporting has increased nationwide. Molecular cluster analysis identifies rapid transmission in varied populations and identifies emerging patterns of rapid transmission in specific population groups, such as PWID, who, in 2015-2016, comprised only 1% of people in such molecular clusters. These data can guide efforts to focus, tailor, and scale up prevention and care services for these populations.

Indexed as

Disease HotspotEpidemiological MonitoringGeographyHIVHIV InfectionsHumansMalePublic HealthSequence Analysis, DNASexual and Gender MinoritiesUnited Statescluster analysisepidemiologyHIV-1intravenouspublic healthsexual and gender minoritiessubstance abuse

Identifiers

PMID33808053
PMCPMC8066706
OpenAlexW3149852832

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.