ReviewMaterials (Basel, Switzerland)2021
A Review on Multiscale Bone Damage: From the Clinical to the Research Perspective.
Review in Materials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Capturing the Multiscale Nature of Bone Behavior: Classical, Data-Driven and Hybrid Techniques.Annals of biomedical engineering · 2026Review
- Integration of Multi-Scale Predictive Tools of Bone Fragility: A Structural and Material Property Perspective.Materials (Basel, Switzerland) · 2025Review
- Microdamage in biological hard tissues and its repair mechanisms.Biomedical engineering online · 2025Review
- Effect of trabecular architectures on the mechanical response in osteoporotic and healthy human bone.Medical & biological engineering & computing · 2024Article
- Osteoporosis and Covid-19: Detected similarities in bone lacunar-level alterations via combined AI and advanced synchrotron testing.Materials & design · 2023Article
- Immunolocalization of Enzymes/Membrane Transporters Related to Bone Mineralization in the Metaphyses of the Long Bones of Parathyroid-Hormone-Administered Mice.Medicina (Kaunas, Lithuania) · 2023Article
- Isolating the Role of Bone Lacunar Morphology on Static and Fatigue Fracture Progression through Numerical Simulations.Materials (Basel, Switzerland) · 2023Article
- Long-Term Cola Intake Does Not Cause Evident Pathological Alterations in the Femoral Bone Microstructure: An Animal Study in Adult Mice.Nutrients · 2023Article
- Superiority of MRI for Evaluation of Sacral Insufficiency Fracture.Journal of clinical medicine · 2022Article
- Mechanical Design Optimization of Prosthetic Hand's Fingers: Novel Solutions towards Weight Reduction.Materials (Basel, Switzerland) · 2022Article
- Torsion-Resistant Structures: A Nature Addressed Solution.Materials (Basel, Switzerland) · 2021Review
- Subchondral Bone Relative Area and Density in Human Osteoarthritic Femoral Heads Assessed with Micro-CT before and after Mechanical Embedding of the Innovative Multi-Spiked Connecting Scaffold for Resurfacing THA Endoprostheses: A Pilot Study.Journal of clinical medicine · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The investigation of bone damage processes is a crucial point to understand the mechanisms of age-related bone fractures. In order to reduce their impact, early diagnosis is key. The intricate architecture of bone and the complexity of multiscale damage processes make fracture prediction an ambitious goal. This review, supported by a detailed analysis of bone damage physical principles, aims at presenting a critical overview of how multiscale imaging techniques could be used to implement reliable and validated numerical tools for the study and prediction of bone fractures. While macro- and meso-scale imaging find applications in clinical practice, micro- and nano-scale imaging are commonly used only for research purposes, with the objective to extract fragility indexes. Those images are used as a source for multiscale computational damage models. As an example, micro-computed tomography (micro-CT) images in combination with micro-finite element models could shed some light on the comprehension of the interaction between micro-cracks and micro-scale bone features. As future insights, the actual state of technology suggests that these models could be a potential substitute for invasive clinical practice for the prediction of age-related bone fractures. However, the translation to clinical practice requires experimental validation, which is still in progress.
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