Evidence map›Paper›PMID 33807880›Full record

ArticleInternational journal of molecular sciences2021

Two Siblings Homozygous for F508del-CFTR Have Varied Disease Phenotypes and Protein Biomarkers.

Zhihong Zhang, Jin Wang, Yanhui H Zhang, Tonia E Gardner, Elizabeth A Fitzpatrick, Weiqiang Zhang

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Zhihong ZhangDepartment of Pediatrics, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Jin WangDepartment of Microbiology, Immunology, and Biochemistry, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Yanhui H ZhangDepartment of Bioscience Research, College of Dentistry, University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0001-8277-8008
Tonia E GardnerDepartment of Pediatrics, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Elizabeth A FitzpatrickDepartment of Microbiology, Immunology, and Biochemistry, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Weiqiang ZhangDepartment of Pediatrics, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0002-7278-5033
University of Tennessee Health Science Center · US

Funding

Characterization of an inhibitory protein complex for cystic fibrosis therapyR01HL123535 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI ZHANG, WEIQIANG · 2014 to 2018
$1.9M
NHLBI NIH HHS R01 HL123535U.S. National Institutes of Health (NIH) HL123535
6 · The paper itself

Abstract

Two siblings with CF are homozygous for F508del (referred to as Subject A and Subject B). Despite having the same CFTR genotype and similar environment, these two subjects exhibited different disease phenotypes. We analyzed their medical records and CF Foundation Registry data and measured inflammatory protein mediators in their sputum samples. Then, we examined the longitudinal relationships between inflammatory markers and disease severity for each subject and compared between them. Subject A presented a more severe disease than Subject B. During the study period, Subject A had two pulmonary exacerbations (PEs) whereas Subject B had one mild PE. The forced expiratory volume in 1 s (FEV

Indexed as

Amino Acid SequenceCystic FibrosisHomozygoteSequence DeletionSiblingsBiomarkersCystic Fibrosis Transmembrane Conductance RegulatorFemaleHumansInflammation MediatorsLeukocyte ElastaseMaleSputumT-Lymphocytes, Helper-InducerBiomarkersCFTR protein, humanCystic Fibrosis Transmembrane Conductance RegulatorInflammation MediatorsLeukocyte ElastasebiomarkersCFTRcystic fibrosis (CF)disease phenotypesF508del-CFTRinfectioninflammation

Identifiers

PMID33807880
PMCPMC7961721
OpenAlexW3134042083

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.