Evidence map›Paper›PMID 33807811›Full record

ArticleJournal of personalized medicine2021

Genetic Polymorphisms of

Diana Z Paderina, Anastasiia S Boiko, Ivan V Pozhidaev, Anna V Bocharova, Irina A Mednova, Olga Yu Fedorenko, Elena G Kornetova, Anton J M Loonen, Arkadiy V Semke, Nikolay A Bokhan and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Biomedicines · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Search for Possible Associations ofPharmacogenomics and personalized medicine · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Diana Z PaderinaMental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, 634014 Tomsk, Russia.ORCID 0000-0002-5546-7316
Anastasiia S BoikoMental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, 634014 Tomsk, Russia.ORCID 0000-0002-2955-9057
Ivan V PozhidaevMental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, 634014 Tomsk, Russia.ORCID 0000-0003-1238-7495
Anna V BocharovaResearch Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences, 634050 Tomsk, Russia.ORCID 0000-0003-2690-8802
Irina A MednovaMental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, 634014 Tomsk, Russia.ORCID 0000-0002-8057-3305
Olga Yu FedorenkoMental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, 634014 Tomsk, Russia.ORCID 0000-0002-9565-6314
Elena G KornetovaMental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, 634014 Tomsk, Russia.ORCID 0000-0002-5179-9727
Anton J M LoonenUnit of PharmacoTherapy, -Epidemiology & -Economics, Groningen Research Institute of Pharmacy, University of Groningen, 9713AV Groningen, The Netherlands.ORCID 0000-0003-4942-6195
Arkadiy V SemkeMental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, 634014 Tomsk, Russia.ORCID 0000-0002-8698-0251
Nikolay A BokhanMental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, 634014 Tomsk, Russia.ORCID 0000-0002-1052-855X
Svetlana A IvanovaMental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, 634014 Tomsk, Russia.ORCID 0000-0001-7078-323X
Russian Academy of Sciences · RUUniversity of Groningen · NL

Funding

Russian Science Foundation 19-75-10012
6 · The paper itself

Abstract

backgroundAntipsychotic-induced metabolic syndrome (MetS) is a multifactorial disease with a genetic predisposition. Serotonin and its receptors are involved in antipsychotic-drug-induced metabolic disorders. The present study investigated the association of nine polymorphisms in the four 5-hydroxytryptamine receptor (

methodsA set of nine single-nucleotide polymorphisms of genes of the serotonergic system was investigated in a population of 475 patients from several Siberian regions (Russia) with a clinical diagnosis of schizophrenia. Genotyping was performed and the results were analyzed using chi-square tests.

resultsPolymorphic variant rs521018 (

conclusionsOur results indicate that allelic variants of

Indexed as

antipsychoticsbody mass indexgenesmetabolic syndromepharmacogeneticsschizophreniaserotoninweight gain

Identifiers

PMID33807811
PMCPMC7999828
OpenAlexW3135702022

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.