Evidence map›Paper›PMID 33807712›Full record

ArticleMolecules (Basel, Switzerland)2021

Tart Cherry Juice and Seeds Affect Pro-Inflammatory Markers in Visceral Adipose Tissue of High-Fat Diet Obese Rats.

Michele Moruzzi, Nora Klöting, Matthias Blüher, Ilenia Martinelli, Seyed Khosrow Tayebati, Maria Gabriella Gabrielli, Proshanta Roy, Maria Vittoria Micioni Di Bonaventura, Carlo Cifani, Giulio Lupidi and 2 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Impact of Obesity-Induced Inflammation on Cardiovascular Diseases (CVD).International journal of molecular sciences · 2021
    Pooled it
  2. Review
  3. WildFood science & nutrition · 2026
    Article
  4. Tart cherries (Frontiers in nutrition · 2026
    Review
  5. Article
  6. Nutrients Lowering Obesity-Linked Chemokines Blamable for Metastasis.International journal of molecular sciences · 2025
    Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Preventive Effects of Anthocyanins fromMolecules (Basel, Switzerland) · 2022
    Article
  14. Article
  15. Effects of Dietary Red Raspberry Consumption on Pre-Diabetes and Type 2 Diabetes Mellitus Parameters.International journal of environmental research and public health · 2021
    Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 3 countries.

Michele MoruzziSchool of Pharmacy, University of Camerino, 62032 Camerino, Italy.
Nora KlötingHelmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, 04103 Leipzig, Germany.ORCID 0000-0002-7625-7254
Matthias BlüherHelmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, 04103 Leipzig, Germany.
Ilenia MartinelliSchool of Pharmacy, University of Camerino, 62032 Camerino, Italy.
Seyed Khosrow TayebatiSchool of Pharmacy, University of Camerino, 62032 Camerino, Italy.ORCID 0000-0002-7219-6917
Maria Gabriella GabrielliSchool of Biosciences and Veterinary Medicine, University of Camerino, 62032 Camerino, Italy.
Proshanta RoySchool of Biosciences and Veterinary Medicine, University of Camerino, 62032 Camerino, Italy.
Maria Vittoria Micioni Di BonaventuraSchool of Pharmacy, University of Camerino, 62032 Camerino, Italy.ORCID 0000-0002-8044-1206
Carlo CifaniSchool of Pharmacy, University of Camerino, 62032 Camerino, Italy.ORCID 0000-0001-6180-828X
Giulio LupidiSchool of Pharmacy, University of Camerino, 62032 Camerino, Italy.
Francesco AmentaSchool of Pharmacy, University of Camerino, 62032 Camerino, Italy.ORCID 0000-0002-0555-1034
Daniele TomassoniSchool of Biosciences and Veterinary Medicine, University of Camerino, 62032 Camerino, Italy.ORCID 0000-0001-9062-3305
Università di Camerino · ITHelmholtz Zentrum München · DE

Funding

University of Camerino Fondo Ateneo Per la Ricerca 2014/2015
6 · The paper itself

Abstract

backgroundTart cherries (

methodsThis study has investigated the potential positive effects of tart cherries on rats with Diet-Induced Obesity (DIO). In particular, the inflammatory status in retroperitoneal (RPW) and perigonadal (PGW) adipose tissue were studied. Rats were fed

resultsNo differences in the weight of RPW and PGW animals were found between DS and DJS groups compared to DIO rats. However, an increase of inflammatory markers was observed in DIO group in comparison with control lean rats. A modulation of these markers was evident upon tart cherry supplementation.

conclusionStudy results suggest that tart cherry enriched-diet did not modify the accumulation of visceral fat, but it decreased inflammatory markers in both tissues. Therefore, this supplementation could be useful, in combination with healthy lifestyles, to modify adipose tissue cell metabolism limiting-obesity related organ damage.

Indexed as

Fruit and Vegetable JuicesAnimalsBiomarkersCD36 AntigensChemokine CCL2Dietary SupplementsDiet, High-FatGene Expression RegulationIntra-Abdominal FatMacrophagesMaleObesityPanniculitisPrunus aviumRatsRats, WistarBiomarkersCcl2 protein, ratCD36 AntigensChemokine CCL2inflammationobesitytart cherriesvisceral adipose tissue

Identifiers

PMID33807712
PMCPMC7961347
OpenAlexW3133773259

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.