Evidence map›Paper›PMID 33807695›Full record

ReviewInternational journal of molecular sciences2021

Recent Updates of Diagnosis, Pathophysiology, and Treatment on Osteoarthritis of the Knee.

Sunhee Jang, Kijun Lee, Ji Hyeon Ju

6 registry-linked trialsOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 6 registered trials, which are not on this map. Cited by 329 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
329citing papers in PubMed, 18 pooled it
61.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06275880 nacompletednot on this mapstarted 2023, after this paper: background citation

Effectiveness of Intra-articular Collagen Polyvinylpyrrolidone in Patients With Symptomatic Gonarthross Attended in Rehabilitation of an IMSS-Yucatán Hospital.

TypeinterventionalSponsorInstituto Mexicano del Seguro SocialRan2023 to 2024Enrolled130ConditionsGonarthrosisArmsIntra-articular infiltration of PVP Collagen, Rehabilitation
NCT06404606 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Effects of Black Cumin and Turmeric Along With Quantum Acoustic Waves on Inflammatory Markers and Pain in Osteoarthritis.

TypeinterventionalSponsorPakistan Society for Rehabilitation of Differently Abled HospitalRan2024 to 2025Enrolled30ConditionsOsteoarthritisArmsBlack cumin and turmeric with Quantum Acoustic Waves (QAW)
NCT07161895 completednot on this mapstarted 2025, after this paper: background citation

Prevalence of Kinesiophobia and Its Effects on Functional Capacity and Pain Severity in Patients With Primary Knee Osteoarthritis

TypeobservationalSponsorAnkara Training and Research HospitalRan2025 to 2026Enrolled84ConditionsKnee Osteoarthritis (Knee OA), OA, Kinesiophobia
NCT07618403 recruitingnot on this mapstarted 2026, after this paper: background citation

Evaluating The Predictive Effect of Treatment Expectations on Response to A Physical Therapy Program in Patients With Knee Osteoarthritis

TypeobservationalSponsorGazi UniversityRan2026 to 2027Enrolled84ConditionsGonarthrosis, Primary, Physical Therapy, Patients' ExpectationsArmsPhysical Therapy
NCT07630259 nacompletednot on this mapstarted 2023, after this paper: background citation

Effects of High-intensity Laser Therapy on Muscle Strength in People With Knee Osteoarthritis

TypeinterventionalSponsorUniversidad Metropolitana de Ciencias de la EducacionRan2023 to 2025Enrolled31ConditionsOsteoarthritic Knee Pain, Osteo Arthritis of the Knee, Osteoarthitis, Osteoarthritis (OA) of the KneeArmsHigh Intensity Laser Therapy, Sham Laser, Exercise
NCT07646366 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Effects of the Egoscue Exercises With and Without Mwm on Pain, Range of Motion, Balance, and Quality of Life Among Patients With Knee Osteoarthritis

TypeinterventionalSponsorRiphah International UniversityRan2026 to 2026Enrolled56ConditionsKnee OsteoarthritisArmsEgoscue exercises with MWM, Egoscue exercises without MWM
3 · Its place in the literature

Who cites it

329 citing papers in PubMed, 18 syntheses or guidelines pooled it, 760 citations in OpenAlex.

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269 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Sunhee JangCatholic iPSC Research Center, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.ORCID 0000-0001-6604-4717
Kijun LeeCatholic iPSC Research Center, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.ORCID 0000-0002-6607-7540
Ji Hyeon JuCatholic iPSC Research Center, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.ORCID 0000-0002-1381-5466
The Catholic University of Korea Seoul St. Mary's Hospital · KR

Funding

Korea Healthcare Technology R&D project, Ministry for Health, Welfare & Family Affairs, Republic of Korea HI20C0495National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) No. 2020R1A2C3004123
6 · The paper itself

Abstract

Osteoarthritis (OA) is a degenerative and chronic joint disease characterized by clinical symptoms and distortion of joint tissues. It primarily damages joint cartilage, causing pain, swelling, and stiffness around the joint. It is the major cause of disability and pain. The prevalence of OA is expected to increase gradually with the aging population and increasing prevalence of obesity. Many potential therapeutic advances have been made in recent years due to the improved understanding of the underlying mechanisms, diagnosis, and management of OA. Embryonic stem cells and induced pluripotent stem cells differentiate into chondrocytes or mesenchymal stem cells (MSCs) and can be used as a source of injectable treatments in the OA joint cavity. MSCs are known to be the most studied cell therapy products in cell-based OA therapy owing to their ability to differentiate into chondrocytes and their immunomodulatory properties. They have the potential to improve cartilage recovery and ultimately restore healthy joints. However, despite currently available therapies and advances in research, unfulfilled medical needs persist for OA treatment. In this review, we focused on the contents of non-cellular and cellular therapies for OA, and briefly summarized the results of clinical trials for cell-based OA therapy to lay a solid application basis for clinical research.

Indexed as

ChondrocytesOsteoarthritis, KneeStem CellsStem Cell TransplantationHumanscell therapydiagnosisembryonic stem cellsinduced pluripotent stem cellsmanagementmesenchymal stem cellsosteoarthritissurgery

Identifiers

PMID33807695
PMCPMC7961389
OpenAlexW3133854280

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.