Evidence map›Paper›PMID 33807679›Full record

ArticleBrain sciences2021

Brain Plasticity Mechanisms Underlying Motor Control Reorganization: Pilot Longitudinal Study on Post-Stroke Subjects.

Marta Gandolla, Lorenzo Niero, Franco Molteni, Elenora Guanziroli, Nick S Ward, Alessandra Pedrocchi

Open access · goldAbstract read
In one paragraph

Article in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Guest Editorial Special Section on Functional Recovery and Brain Plasticity.IEEE open journal of engineering in medicine and biology · 2023
    Article
  7. Article
  8. Article
  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Marta GandollaNearLab@Lecco, Polo Territoriale di Lecco, Politecnico di Milano, Via Gaetano Previati, 1/c, 23900 Lecco, Italy.ORCID 0000-0001-5237-714X
Lorenzo NieroNearLab@Lecco, Polo Territoriale di Lecco, Politecnico di Milano, Via Gaetano Previati, 1/c, 23900 Lecco, Italy.
Franco MolteniVilla Beretta Rehabilitation Center, Valduce Hospital, Via N. Sauro, 17, 23845 Costa Masnaga, Italy.
Elenora GuanziroliVilla Beretta Rehabilitation Center, Valduce Hospital, Via N. Sauro, 17, 23845 Costa Masnaga, Italy.ORCID 0000-0002-7512-5372
Nick S WardDepartment of Movement and Clinical Neuroscience, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK.
Alessandra PedrocchiNearLab@Lecco, Polo Territoriale di Lecco, Politecnico di Milano, Via Gaetano Previati, 1/c, 23900 Lecco, Italy.
Politecnico di Milano · ITOspedale Valduce · ITNational Hospital for Neurology and Neurosurgery · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Functional Electrical Stimulation (FES) has demonstrated to improve walking ability and to induce the carryover effect, long-lasting persisting improvement. Functional magnetic resonance imaging has been used to investigate effective connectivity differences and longitudinal changes in a group of chronic stroke patients that attended a FES-based rehabilitation program for foot-drop correction, distinguishing between carryover effect responders and non-responders, and in comparison with a healthy control group. Bayesian hierarchical procedures were employed, involving nonlinear models at within-subject level-dynamic causal models-and linear models at between-subjects level. Selected regions of interest were primary sensorimotor cortices (M1, S1), supplementary motor area (SMA), and angular gyrus. Our results suggest the following: (i) The ability to correctly plan the movement and integrate proprioception information might be the features to update the motor control loop, towards the carryover effect, as indicated by the reduced sensitivity to proprioception input to S1 of FES non-responders; (ii) FES-related neural plasticity supports the active inference account for motor control, as indicated by the modulation of SMA and M1 connections to S1 area; (iii) SMA has a dual role of higher order motor processing unit responsible for complex movements, and a superintendence role in suppressing standard motor plans as external conditions changes.

Indexed as

carryover effectdynamic causal modeling (DCM)fMRIfunctional electrical stimulation (FES)parametric empirical bayes (PEB)

Identifiers

PMID33807679
PMCPMC8002039
OpenAlexW3109982854

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.