ArticleInternational journal of environmental research and public health2021
A Novel Approach to Derive the Predicted No-Effect Concentration (PNEC) of Benzophenone-3 (BP-3) Using the Species Sensitivity Distribution (SSD) Method: Suggestion of a New PNEC Value for BP-3.
Article in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Environmental Risk Assessment in Pharmaceutical Regulation: A Comparative Review of EMA, U.S. FDA and CDSCO Guidelines.Therapeutic innovation & regulatory science · 2026Review
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Authors and funding
4 authors.
Funding
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Abstract
The necessity for the aquatic ecological risk assessment for benzophenone-3 (BP-3) is increasing due to its high toxic potential and high detection frequency in freshwater. The initial step in the ecological risk assessment is to determine predicted no-effect concentration (PNEC). This study derived PNEC of BP-3 in freshwater using a species sensitivity distribution (SSD) approach, whilst existing PNECs are derived using assessment factor (AF) approaches. A total of eight chronic toxicity values, obtained by toxicity testing and a literature survey, covering four taxonomic classes (fish, crustaceans, algae, and cyanobacteria) were used for PNEC derivation. Therefore, the quantity and quality of the toxicity data met the minimum requirements for PNEC derivation using an SSD approach. The PNEC derived in this study (73.3 μg/L) was far higher than the environmental concentration detected in freshwater (up to 10.4 μg/L) as well as existing PNECs (0.67~1.8 μg/L), mainly due to the difference in the PNEC derivation methodology (i.e., AF vs. SSD approach). Since the SSD approach is regarded as more reliable than the AF approach, we recommend applying the PNEC value derived in this study for the aquatic ecological risk assessment of BP-3, as the use of the existing PNEC values seems to unnecessarily overestimate the potential ecological risk of BP-3 in freshwater.
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