ArticleAnimals : an open access journal from MDPI2021
Changes in Blood Metabolites and Immune Cells in Holstein and Jersey Dairy Cows by Heat Stress.
Article in Animals : an open access journal from MDPI, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
23 citing papers in PubMed, 63 citations in OpenAlex.
- Generation-Specific Heterosis in Lactation, Reproduction, and Blood Transcriptomic Profiles of Chinese Simmental × Holstein Crossbred Cows.Animals : an open access journal from MDPI · 2026Article
- Consequences of Heat Stress on Physiology, Microbiome Dynamics, and Multi-Omics in Dairy Cows: More than Meets the Eye.Biology · 2026Review
- Integrating biomarkers and artificial intelligence for precision diagnostics in cattle health and herd management: a review.Veterinary research communications · 2026Review
- Changes in leukocyte indices of Holstein cows under prolonged heat stress conditions.Tropical animal health and production · 2026Article
- Integrated metabolome and immunity analysis of immune-physiological responses in dairy cows under heat stress condition.Animal bioscience · 2025Article
- Calcium Metabolism, Immunity and Reproduction in Early Postpartum Dairy Cows.Animals : an open access journal from MDPI · 2025Article
- Impact of Blood Metabolic Profile and Ingestive Behaviours Registered with Noseband Sensor on Methane Emission During Transition Period in Dairy Cows.Life (Basel, Switzerland) · 2025Article
- Influence of cow and heifer categories on the hematology of Murrah buffaloes (Brazilian journal of veterinary medicine · 2025Article
- Proteomic identification of potential biomarkers for heat tolerance in Caracu beef cattle using high and low thermotolerant groups.BMC genomics · 2024Article
- Short-Term Effects of Heat Stress on Cow Behavior, Registered by Innovative Technologies and Blood Gas Parameters.Animals : an open access journal from MDPI · 2024Article
- Influence of Heat Stress on Body Surface Temperature and Blood Metabolic, Endocrine, and Inflammatory Parameters and Their Correlation in Cows.Metabolites · 2024Article
- The autumn low milk yield syndrome in Brown Swiss cows in continental climates: hypotheses and facts.Veterinary research communications · 2024Article
- Metabolomics-based study of the effect of dietary N-carbamoylglutamic acid addition to heifers in late pregnancy on newborn calves.Frontiers in veterinary science · 2024Article
- Effects of heat-stress-reducing systems on blood constituents, milk production and milk quality of Holstein and Jersey cows and heifers on pasture.Tropical animal health and production · 2023Article
- A review of dairy cattle heat stress mitigation in Indonesia.Veterinary world · 2023Review
- Genome-wide expression analysis reveals different heat shock responses in indigenous (Bos indicus) and crossbred (Bos indicus X Bos taurus) cattle.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2023Article
- Effects of Heat Stress in Dairy Cows Raised in the Confined System: A Scientometric Review.Animals : an open access journal from MDPI · 2023Review
- Influence of dietary organic trace minerals on enteric methane emissions and rumen microbiota of heat-stressed dairy steers.Journal of animal science and technology · 2023Article
- Higher Concentration of Dietary Selenium, Zinc, and Copper Complex Reduces Heat Stress-Associated Oxidative Stress and Metabolic Alteration in the Blood of Holstein and Jersey Steers.Animals : an open access journal from MDPI · 2022Article
- Effects of High Heat Load Conditions on Blood Constituent Concentrations in Dorper, Katahdin, and St. Croix Sheep from Different Regions of the USA.Animals : an open access journal from MDPI · 2022Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Owing to increasing global temperatures, heat stress is a major problem affecting dairy cows, and abnormal metabolic responses during heat stress likely influence dairy cow immunity. However, the mechanism of this crosstalk between metabolism and immunity during heat stress remains unclear. We used two representative dairy cow breeds, Holstein and Jersey, with distinct heat-resistance characteristics. To understand metabolic and immune responses to seasonal changes, normal environmental and high-heat environmental conditions, we assessed blood metabolites and immune cell populations. In biochemistry analysis from sera, we found that variety blood metabolites were decreased in both Holstein and Jersey cows by heat stress. We assessed changes in immune cell populations in peripheral blood mononuclear cells (PBMCs) using flow cytometry. There were breed-specific differences in immune-cell population changes. Heat stress only increased the proportion of B cells (CD4-CD21+) and heat stress tended to decrease the proportion of monocytes (CD11b+CD172a+) in Holstein cows. Our findings expand the understanding of the common and specific changes in metabolism and immune response of two dairy cow breeds under heat stress conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.