ArticleViruses2021
Different Cross-Reactivities of IgM Responses in Dengue, Zika and Tick-Borne Encephalitis Virus Infections.
Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Dominance of DENV-1 and Flavivirus Serological Cross-Reactivity During the 2016 Dengue Outbreak in Vietnam.Journal of medical virology · 2025Article
- False-positive dengue IgM inASM case reports · 2025Article
- Ultrasensitive Peptide-Based Electrochemical Biosensor for Universal Diagnostic of Dengue.Biosensors · 2025Article
- Clinical spectrum and risk factors of severe dengue infection: findings from the 2023 dengue outbreak in Bangladesh.BMC infectious diseases · 2025Article
- Comprehensive analysis of intervention and control studies for the computational identification of dengue biomarker genes.PLoS neglected tropical diseases · 2025Article
- A Retrospective Sero-Surveillance Study for Antibodies Against Tick-Borne Encephalitis Virus in Norway.Viruses · 2025Article
- Epidemiological, virological and clinical characterization of a Dengue/Zika outbreak in the Caribbean region of Costa Rica 2017-2018.Frontiers in cellular and infection microbiology · 2024Article
- Clinical, Hematological, and Biochemical Profile in Seropositive Dengue Cases at a Tertiary Care Hospital in Nepal.Journal of tropical medicine · 2024Article
- Effect of previous heterologous flavivirus vaccinations on human antibody responses in tick-borne encephalitis and dengue virus infections.Journal of medical virology · 2023Article
- Cross-Reactive Antibodies in Tick-Borne Encephalitis: Case Report and Literature Review.Antibodies (Basel, Switzerland) · 2022Article
- Presumed Protective Role for Anti-Hepatitis B Virus Antibodies Against COVID-19 Severe Cases: A Clinical Study ConfirmingFrontiers in medicine · 2022Article
- Zika a Vector Borne Disease Detected in Newer States of India Amidst the COVID-19 Pandemic.Frontiers in microbiology · 2022Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Flaviviruses circulate worldwide and cause a number of medically relevant human diseases, such as dengue, Zika, yellow fever, and tick-borne encephalitis (TBE). Serology plays an important role in the diagnosis of flavivirus infections, but can be impeded by antigenic cross-reactivities among flaviviruses. Therefore, serological diagnosis of a recent infection can be insufficiently specific, especially in areas where flaviviruses co-circulate and/or vaccination coverage against certain flaviviruses is high. In this study, we developed a new IgM assay format, which is well suited for the specific diagnosis of TBE, Zika and dengue virus infections. In the case of TBE and Zika, the IgM response proved to be highly specific for the infecting virus. In contrast, primary dengue virus infections induced substantial amounts of cross-reactive IgM antibodies, which is most likely explained by structural peculiarities of dengue virus particles. Despite the presence of cross-reactive IgM, the standardized nature and the quantitative read-out of the assay even allowed the serotype-specific diagnosis of recent dengue virus infections in most instances.
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