Evidence map›Paper›PMID 33807319›Full record

ArticleNutrients2021

Antenatal Determinants of Childhood Obesity in High-Risk Offspring: Protocol for the DiGest Follow-Up Study.

Danielle Jones, Emanuella De Lucia Rolfe, Kirsten L Rennie, Linda M Oude Griep, Laura C Kusinski, Deborah J Hughes, Soren Brage, Ken K Ong, Kathryn Beardsall, Claire L Meek

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Danielle JonesMRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK.
Emanuella De Lucia RolfeNIHR Cambridge Biomedical Research Centre-Diet, Anthropometry and Physical Activity Group, MRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK.
Kirsten L RennieNIHR Cambridge Biomedical Research Centre-Diet, Anthropometry and Physical Activity Group, MRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK.ORCID 0000-0003-2690-1934
Linda M Oude GriepNIHR Cambridge Biomedical Research Centre-Diet, Anthropometry and Physical Activity Group, MRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK.ORCID 0000-0001-7697-7473
Laura C KusinskiInstitute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.
Deborah J HughesInstitute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.
Soren BrageMRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK.
Ken K OngMRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK.
Kathryn BeardsallDepartment of Paediatric Medicine, University of Cambridge, Cambridge CB2 0QQ, UK.
Claire L MeekInstitute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.
University of Cambridge · GB

Funding

Diabetes UK 17/0005712Medical Research Council MC_UU_00006/2Medical Research Council MC_UU_00006/4
6 · The paper itself

Abstract

Childhood obesity is an area of intense concern internationally and is influenced by events during antenatal and postnatal life. Although pregnancy complications, such as gestational diabetes and large-for-gestational-age birthweight have been associated with increased obesity risk in offspring, very few successful interventions in pregnancy have been identified. We describe a study protocol to identify if a reduced calorie diet in pregnancy can reduce adiposity in children to 3 years of age. The dietary intervention in gestational diabetes (DiGest) study is a randomised, controlled trial of a reduced calorie diet provided by a whole-diet replacement in pregnant women with gestational diabetes. Women receive a weekly dietbox intervention from enrolment until delivery and are blinded to calorie allocation. This follow-up study will assess associations between a reduced calorie diet in pregnancy with offspring adiposity and maternal weight and glycaemia. Anthropometry will be performed in infants and mothers at 3 months, 1, 2 and 3 years post-birth. Glycaemia will be assessed using bloodspot C-peptide in infants and continuous glucose monitoring with HbA1c in mothers. Data regarding maternal glycaemia in pregnancy, maternal nutrition, infant birthweight, offspring feeding behaviour and milk composition will also be collected. The DiGest follow-up study is expected to take 5 years, with recruitment finishing in 2026.

Indexed as

Clinical ProtocolsPediatric ObesityAdultBlood GlucoseBody WeightChildDiabetes, GestationalFemaleFollow-Up StudiesHumansLife StyleMaternal Nutritional Physiological PhenomenaPregnancyPrenatal CareRisk FactorsBlood Glucoseadipositycalorie restrictionchildhood obesitycomplex interventiongestational diabetes mellituslarge for gestational agematernal weight gainpregnancypreventionrandomised controlled trialstudy protocoltype 2 diabetes

Identifiers

PMID33807319
PMCPMC8067255
OpenAlexW3144821821

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.