Evidence map›Paper›PMID 33807248›Full record

ArticlePharmaceuticals (Basel, Switzerland)2021

Potent Antiviral Activity against HSV-1 and SARS-CoV-2 by Antimicrobial Peptoids.

Gill Diamond, Natalia Molchanova, Claudine Herlan, John A Fortkort, Jennifer S Lin, Erika Figgins, Nathen Bopp, Lisa K Ryan, Donghoon Chung, Robert Scott Adcock and 2 more

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 54 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Antiparasitic effect of peptoids againstMicrobiology (Reading, England) · 2025
    Article
  6. Membrane-Targeting Antivirals.International journal of molecular sciences · 2025
    Review
  7. Structural Optimization of Antifungal Peptoids targetingACS medicinal chemistry letters · 2025
    Article
  8. Review
  9. Cryogenic Electron Microscopy of Rift Valley Fever Virus.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. The activity of antimicrobial peptoids against multidrug-resistant ocular pathogens.Contact lens & anterior eye : the journal of the British Contact Lens Association · 2024
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Gill DiamondDepartment of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Louisville, KY 40202, USA.ORCID 0000-0002-3596-9773
Natalia MolchanovaDepartment of Bioengineering, Stanford University School of Medicine, Stanford, CA 94305, USA.
Claudine HerlanDepartment of Bioengineering, Stanford University School of Medicine, Stanford, CA 94305, USA.
John A FortkortDepartment of Bioengineering, Stanford University School of Medicine, Stanford, CA 94305, USA.
Jennifer S LinDepartment of Bioengineering, Stanford University School of Medicine, Stanford, CA 94305, USA.
Erika FigginsDepartment of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Louisville, KY 40202, USA.
Nathen BoppDepartment of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Lisa K RyanDivision of Infectious Diseases and Global Medicine, Department of Medicine, University of Florida School of Medicine, Gainesville, FL 32601, USA.ORCID 0000-0001-6422-7720
Donghoon ChungCenter for Predictive Medicine, Department of Microbiology, School of Medicine, University of Louisville, Louisville, KY 40202, USA.
Robert Scott AdcockCenter for Predictive Medicine, Department of Microbiology, School of Medicine, University of Louisville, Louisville, KY 40202, USA.
Michael ShermanDepartment of Biochemistry and Molecular Biology, Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch, Galveston, TX 77555, USA.ORCID 0000-0002-3680-8066
Annelise E BarronDepartment of Bioengineering, Stanford University School of Medicine, Stanford, CA 94305, USA.
University of Louisville · USStanford University · USThe University of Texas Medical Branch at Galveston · USKarlsruhe Institute of Technology · DELawrence Berkeley National Laboratory · USUniversity of Florida · US

Funding

Role of Innate Immune Dysregulation in the Etiology of DementiaDP1AG072438 · NIA · STANFORD UNIVERSITY · PI BARRON, ANNELISE EMILY · 2020 to 2024
$5.2M
NIA NIH HHS DP1 AG072438NIH HHS 1DP1 OD029517-01
6 · The paper itself

Abstract

Viral infections, such as those caused by Herpes Simplex Virus-1 (HSV-1) and SARS-CoV-2, affect millions of people each year. However, there are few antiviral drugs that can effectively treat these infections. The standard approach in the development of antiviral drugs involves the identification of a unique viral target, followed by the design of an agent that addresses that target. Antimicrobial peptides (AMPs) represent a novel source of potential antiviral drugs. AMPs have been shown to inactivate numerous different enveloped viruses through the disruption of their viral envelopes. However, the clinical development of AMPs as antimicrobial therapeutics has been hampered by a number of factors, especially their enzymatically labile structure as peptides. We have examined the antiviral potential of peptoid mimics of AMPs (sequence-specific

Indexed as

air-liquid interfaceantiviralsCOVID-19cytotoxicityHSV-1LL-37membrane disruptionpeptoidsSARS-CoV-2

Identifiers

PMID33807248
PMCPMC8066833
OpenAlexW3150210131

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.