ArticleCancers2021
Multidimensional Diffusion Magnetic Resonance Imaging for Characterization of Tissue Microstructure in Breast Cancer Patients: A Prospective Pilot Study.
Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 42 citations in OpenAlex.
- Diffusion-relaxation MRI as virtual histology: separable microstructural signatures of AD pathology in ex vivo human brain.Research square · 2026Article
- Separable multidimensional MRI signatures of cellular and structural pathology in Alzheimer's disease.bioRxiv : the preprint server for biology · 2026Article
- Frequency-Dependent Diffusion-Relaxation Distribution MRI: Scan-Rescan Reproducibility Ex Vivo and Caveats.NMR in biomedicine · 2026Article
- Advanced breast diffusion-weighted imaging: what are the next steps? A proposal from the EUSOBI International Breast Diffusion-weighted Imaging working group.European radiology · 2025Review
- Ex vivo massively multidimensional diffusion-relaxation correlation MRI: scan-rescan reproducibility and caveats.bioRxiv : the preprint server for biology · 2025Article
- Frequency-dependence in multidimensional diffusion-relaxation correlation MRI of the brain: Overfitting or meaningful parameter?Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Imaging evaluation focused on microstructural tissue changes using tensor-valued diffusion encoding in breast cancers after neoadjuvant chemotherapy: is it a promising way forward?Gland surgery · 2024Article
- In vivo disentanglement of diffusion frequency-dependence, tensor shape, and relaxation using multidimensional MRI.Human brain mapping · 2024Article
- Variability of multidimensional diffusion-relaxation MRI estimates in the human brain.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Article
- Cardiac q-space trajectory imaging by motion-compensated tensor-valued diffusion encoding in human heart in vivo.Magnetic resonance in medicine · 2023Article
- Mapping the individual human cortex using multidimensional MRI and unsupervised learning.Brain communications · 2023Article
- Multidimensional encoding of restricted and anisotropic diffusion by double rotation of theMagnetic resonance (Gottingen, Germany) · 2023Article
- Nonparametric 5D D-RJournal of magnetic resonance (San Diego, Calif. : 1997) · 2022Article
- Anisotropy measure from three diffusion-encoding gradient directions.Magnetic resonance imaging · 2022Article
- Clinical experience of tensor-valued diffusion encoding for microstructure imaging by diffusional variance decomposition in patients with breast cancer.Quantitative imaging in medicine and surgery · 2022Article
- Diagnostic Performance of Diffusion Kurtosis Imaging for Benign and Malignant Breast Lesions: A Systematic Review and Meta-Analysis.Applied bionics and biomechanics · 2022Review
- Multidimensional MRI for Characterization of Subtle Axonal Injury Accelerated Using an Adaptive Nonlocal Multispectral Filter.Frontiers in physics · 2021Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
Abstract
Diffusion-weighted imaging is a non-invasive functional imaging modality for breast tumor characterization through apparent diffusion coefficients. Yet, it has so far been unable to intuitively inform on tissue microstructure. In this IRB-approved prospective study, we applied novel multidimensional diffusion (MDD) encoding across 16 patients with suspected breast cancer to evaluate its potential for tissue characterization in the clinical setting. Data acquired via custom MDD sequences was processed using an algorithm estimating non-parametric diffusion tensor distributions. The statistical descriptors of these distributions allow us to quantify tissue composition in terms of metrics informing on cell densities, shapes, and orientations. Additionally, signal fractions from specific cell types, such as elongated cells (bin1), isotropic cells (bin2), and free water (bin3), were teased apart. Histogram analysis in cancers and healthy breast tissue showed that cancers exhibited lower mean values of "size" (1.43 ± 0.54 × 10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.