ArticleViruses2021
IgA-Dominant Infection-Associated Glomerulonephritis Following SARS-CoV-2 Infection.
Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Ascertaining the mechanistic etiology of COVID-associated glomerulonephritis: a systematic review.Frontiers in medicine · 2025Pooled it
- Coronavirus disease 2019, vaccination against coronavirus and immunoglobulin A-mediated diseases: systematic literature review.Journal of autoimmunity · 2022Pooled it
- What is the spectrum of kidney pathology associated with COVID-19?Internal medicine journal · 2024Review
- The impact of mild and moderate COVID-19 infection on the progression of kidney dysfunction in patients with IgA nephropathy.Clinical kidney journal · 2024Article
- Clinical and pathological findings of IgA nephropathy following SARS-CoV-2 infection.Clinical and experimental medicine · 2024Article
- Autoimmunity and Infection in Glomerular Disease.Microorganisms · 2023Review
- COVID-19 and Glomerular Diseases.Kidney international reports · 2023Review
- Multisystem Inflammatory Syndrome in Adults Associated with Recent Infection with COVID-19.Diagnostics (Basel, Switzerland) · 2023Article
- Characteristics of children with IgA nephropathy.Pediatric research · 2023Article
- Newly-diagnosed immunoglobulin A nephropathy with increased plasma galactose-deficient-IgAThe Journal of international medical research · 2022Article
- Review
- Multisystem inflammatory syndrome in adults: a case report and review of the literature.Journal of medical case reports · 2022Review
- A Case of Immunoglobulin A (IgA)-Dominant Infection-Related Glomerulonephritis Treated With Plasmapheresis.Cureus · 2022Article
- Kidney injury associated with COVID-19 infection and vaccine: A narrative review.Frontiers in medicine · 2022Review
- Article
- Current Understanding of Clinical Manifestations of COVID-19 in Glomerular Disease.Glomerular diseases · 2021Review
- Respiratory Nasal Mucosa in Chronic Rhinosinusitis with Nasal Polyps versus COVID-19: Histopathology, Electron Microscopy Analysis and Assessing of Tissue Interleukin-33.Journal of clinical medicine · 2021Article
- Evidence of SARS-CoV-2 Virus in the Middle Ear of Deceased COVID-19 Patients.Diagnostics (Basel, Switzerland) · 2021Article
- Acute COVID-19 Vaccine-Associated Glomerulonephritis: An Effect of Vaccination or the Infection Itself?Indian journal of nephrologyArticle
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The renal involvement of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been reported. The etiology of kidney injury appears to be tubular, mainly due to the expression of angiotensin-converting enzyme 2, the key joint receptor for SARS-CoV-2; however, cases with glomerular implication have also been documented. The multifactorial origin of this renal involvement could include virus-mediated injury, cytokine storm, angiotensin II pathway activation, complement dysregulation, hyper-coagulation, and microangiopathy. We present the renal histological findings from a patient who developed acute kidney injury and de novo nephrotic syndrome, highly suggestive of acute IgA-dominant infection-associated glomerulonephritis (IgA-DIAGN) after SARS-CoV-2 infection, as evidenced by the presence of this virus detected in the renal tissue of the patient via immunohistochemistry assay. In summary, we document the first case of IgA-DIAGN associated to SARS-CoV-2. Thus, SARS-CoV-2 S may act as a super antigen driving the development of multisystem inflammatory syndrome as well as cytokine storm in patients affected by COVID-19, reaching the glomerulus and leading to the development of this novel IgA-DIAGN.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.