Evidence map›Paper›PMID 33807118›Full record

ArticleMicromachines2021

Rapid Fabrication of Microfluidic Devices for Biological Mimicking: A Survey of Materials and Biocompatibility.

Hui Ling Ma, Ana Carolina Urbaczek, Fayene Zeferino Ribeiro de Souza, Paulo Augusto Gomes Garrido Carneiro Leão, Janice Rodrigues Perussi, Emanuel Carrilho

Open access · goldAbstract read
In one paragraph

Article in Micromachines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Hui Ling MaInstituto de Química de São Carlos, Universidade de São Paulo, São Carlos 13566-590, SP, Brazil.ORCID 0000-0002-8059-435X
Ana Carolina UrbaczekInstituto de Química de São Carlos, Universidade de São Paulo, São Carlos 13566-590, SP, Brazil.
Fayene Zeferino Ribeiro de SouzaInstituto de Química de São Carlos, Universidade de São Paulo, São Carlos 13566-590, SP, Brazil.ORCID 0000-0002-3053-1828
Paulo Augusto Gomes Garrido Carneiro LeãoInstituto de Química de São Carlos, Universidade de São Paulo, São Carlos 13566-590, SP, Brazil.
Janice Rodrigues PerussiInstituto de Química de São Carlos, Universidade de São Paulo, São Carlos 13566-590, SP, Brazil.
Emanuel CarrilhoInstituto de Química de São Carlos, Universidade de São Paulo, São Carlos 13566-590, SP, Brazil.ORCID 0000-0001-7351-8220
Universidade de São Paulo · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico CNPq (150250/2014-2, 150096/2014-3, 400168/2013-8, 311323/2011-1, and 482696/2011-7)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Finance Code 001Fundação de Amparo à Pesquisa do Estado de São Paulo Process 2014/50867-3
6 · The paper itself

Abstract

Microfluidics is an essential technique used in the development of in vitro models for mimicking complex biological systems. The microchip with microfluidic flows offers the precise control of the microenvironment where the cells can grow and structure inside channels to resemble in vivo conditions allowing a proper cellular response investigation. Hence, this study aimed to develop low-cost, simple microchips to simulate the shear stress effect on the human umbilical vein endothelial cells (HUVEC). Differentially from other biological microfluidic devices described in the literature, we used readily available tools like heat-lamination, toner printer, laser cutter and biocompatible double-sided adhesive tapes to bind different layers of materials together, forming a designed composite with a microchannel. In addition, we screened alternative substrates, including polyester-toner, polyester-vinyl, glass, Permanox

Indexed as

glassHUVEC- human umbilical vein endothelial cell lineorgan-on-chippolyester-tonerpolyester-vinylpolystyreneshear stress

Identifiers

PMID33807118
PMCPMC8005101
OpenAlexW3135939695

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.