Evidence map›Paper›PMID 33807089›Full record

ArticleInternational journal of molecular sciences2021

Late Health Effects of Partial Body Irradiation Injury in a Minipig Model Are Associated with Changes in Systemic and Cardiac IGF-1 Signaling.

Bernadette Hritzo, Saeed Y Aghdam, Betre Legesse, Amandeep Kaur, Maohua Cao, Marjan Boerma, Nabarun Chakraborty, George Dimitrov, Aarti Gautam, Rasha Hammamieh and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Bernadette HritzoArmed Forces Radiobiology Research Institute, Bethesda, MD 20889, USA.
Saeed Y AghdamArmed Forces Radiobiology Research Institute, Bethesda, MD 20889, USA.
Betre LegesseArmed Forces Radiobiology Research Institute, Bethesda, MD 20889, USA.
Amandeep KaurArmed Forces Radiobiology Research Institute, Bethesda, MD 20889, USA.
Maohua CaoDepartment of Endodontics, Texas A&M College of Dentistry, Dallas, TX 75246, USA.
Marjan BoermaDepartment of Pharmaceutical Sciences, University of Arkansas for Medical Sciences (UAMS), Little Rock, AR 72205, USA.ORCID 0000-0003-2249-5203
Nabarun ChakrabortyMedical Readiness Systems Biology, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
George DimitrovMedical Readiness Systems Biology, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Aarti GautamThe Geneva Foundation, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Rasha HammamiehThe Geneva Foundation, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
William WilkinsArmed Forces Radiobiology Research Institute, Bethesda, MD 20889, USA.
Alena TsioplayaArmed Forces Radiobiology Research Institute, Bethesda, MD 20889, USA.
Gregory P Holmes-HamptonArmed Forces Radiobiology Research Institute, Bethesda, MD 20889, USA.
Maria MoroniArmed Forces Radiobiology Research Institute, Bethesda, MD 20889, USA.
The Geneva Foundation · USUniversity of Arkansas for Medical Sciences · US

Funding

National Institute of Allergy and Infectious Diseases AAI-12044-001-04000
6 · The paper itself

Abstract

Clinical, epidemiological, and experimental evidence demonstrate non-cancer, cardiovascular, and endocrine effects of ionizing radiation exposure including growth hormone deficiency, obesity, metabolic syndrome, diabetes, and hyperinsulinemia. Insulin-like growth factor-1 (IGF-1) signaling perturbations are implicated in development of cardiovascular disease and metabolic syndrome. The minipig is an emerging model for studying radiation effects given its high analogy to human anatomy and physiology. Here we use a minipig model to study late health effects of radiation by exposing male Göttingen minipigs to 1.9-2.0 Gy X-rays (lower limb tibias spared). Animals were monitored for 120 days following irradiation and blood counts, body weight, heart rate, clinical chemistry parameters, and circulating biomarkers were assessed longitudinally. Collagen deposition, histolopathology, IGF-1 signaling, and mRNA sequencing were evaluated in tissues. Our findings indicate a single exposure induced histopathological changes, attenuated circulating IGF-1, and disrupted cardiac IGF-1 signaling. Electrolytes, lipid profiles, liver and kidney markers, and heart rate and rhythm were also affected. In the heart, collagen deposition was significantly increased and transforming growth factor beta-1 (TGF-beta-1) was induced following irradiation; collagen deposition and fibrosis were also observed in the kidney of irradiated animals. Our findings show Göttingen minipigs are a suitable large animal model to study long-term effects of radiation exposure and radiation-induced inhibition of IGF-1 signaling may play a role in development of late organ injuries.

Indexed as

BiomarkersAnimalsBlood CellsBody WeightCollagenDisease Models, AnimalDose-Response Relationship, RadiationFibrosisGene Expression RegulationHeart RateHematopoiesisInsulin-Like Growth Factor ILipid MetabolismMyocardiumOrgan SpecificityRadiation InjuriesBiomarkersCollagenInsulin-Like Growth Factor IGöttingen minipigIGF-1Insulin-like growth factor-1late effectspartial body irradiationradiation

Identifiers

PMID33807089
PMCPMC8005067
OpenAlexW3138831348

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.