Loss of BOK Has a Minor Impact on Acetaminophen Overdose-Induced Liver Damage in Mice.

Samara Naim, Yuniel Fernandez-Marrero, Simone de Brot, Daniel Bachmann, Thomas Kaufmann

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Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.7field-weighted citation impact, top 31% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Samara NaimInstitute of Pharmacology, University of Bern, Inselspital, INO-F, 3010 Bern, Switzerland.

Yuniel Fernandez-MarreroInstitute of Pharmacology, University of Bern, Inselspital, INO-F, 3010 Bern, Switzerland.

Simone de BrotCOMPATH, Institute of Animal Pathology, University of Bern, Laenggassstrasse 122, CH-3012 Bern, Switzerland.ORCID 0000-0003-3049-0103

Daniel BachmannInstitute of Pharmacology, University of Bern, Inselspital, INO-F, 3010 Bern, Switzerland.

Thomas KaufmannInstitute of Pharmacology, University of Bern, Inselspital, INO-F, 3010 Bern, Switzerland.ORCID 0000-0001-9906-874X

University of Bern · CH

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 31003A-173006

6 · The paper itself

Abstract

Acetaminophen (APAP) is one of the most commonly used analgesic and anti-pyretic drugs, and APAP intoxication is one of the main reasons for liver transplantation following liver failure in the Western world. While APAP poisoning ultimately leads to liver necrosis, various programmed cell death modalities have been implicated, including ER stress-triggered apoptosis. The BCL-2 family member BOK (BCL-2-related ovarian killer) has been described to modulate the unfolded protein response and to promote chemical-induced liver injury. We therefore investigated the impact of the loss of BOK following APAP overdosing in mice. Surprisingly, we observed sex-dependent differences in the activation of the unfolded protein response (UPR) in both wildtype (WT) and

Indexed as

Genetic Predisposition to DiseaseAcetaminophenAnimalsApoptosisChemical and Drug Induced Liver InjuryCytochrome P-450 CYP2E1Drug OverdoseEndoplasmic Reticulum StressFemaleGene Expression RegulationGenes, p53MaleMiceMice, KnockoutProto-Oncogene Proteins c-bcl-2Severity of Illness IndexAcetaminophenBok protein, mousecytochrome P-450 2E1, mouseCytochrome P-450 CYP2E1Proto-Oncogene Proteins c-bcl-2acetaminophenapoptosisBCL-2 familyBOKER stressnecrosisUPR

Identifiers

PMID33807047

DOI10.3390/ijms22063281

PMCPMC8004760

OpenAlexW3137866140

What OpenQuestion holds

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LicenceCC BY

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.