Evidence map›Paper›PMID 33807023›Full record

ArticleCancers2021

miRNA Expression Characterizes Histological Subtypes and Metastasis in Penile Squamous Cell Carcinoma.

Hiresh Ayoubian, Joana Heinzelmann, Sebastian Hölters, Oybek Khalmurzaev, Alexey Pryalukhin, Philine Loertzer, Julia Heinzelbecker, Stefan Lohse, Carol Geppert, Hagen Loertzer and 6 more

Abstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. The role and mechanism of human papillomavirus in urinary system tumors.The Journal of international medical research · 2025
    Review
  3. Exosomal ncRNAs in reproductive cancers†.Biology of reproduction · 2025
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Upregulated miRNAs on theFrontiers in genetics · 2022
    Article
  11. Non-Coding RNA in Penile Cancer.Frontiers in oncology · 2022
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Hiresh AyoubianDepartment of Urology and Paediatric Urology, Saarland University, 66421 Homburg, Germany.
Joana HeinzelmannDepartment of Urology and Paediatric Urology, Saarland University, 66421 Homburg, Germany.ORCID 0000-0003-0384-0622
Sebastian HöltersDepartment of Urology and Paediatric Urology, Saarland University, 66421 Homburg, Germany.
Oybek KhalmurzaevDepartment of Urology and Paediatric Urology, Saarland University, 66421 Homburg, Germany.
Alexey PryalukhinInstitute of Pathology, Saarland University Medical Centre, 66421 Homburg, Germany.
Philine LoertzerDepartment of Urology and Paediatric Urology, Saarland University, 66421 Homburg, Germany.
Julia HeinzelbeckerDepartment of Urology and Paediatric Urology, Saarland University, 66421 Homburg, Germany.
Stefan LohseInstitute of Virology, Saarland University, 66421 Homburg, Germany.ORCID 0000-0003-2529-1900
Carol GeppertInstitute of Pathology, University Erlangen-Nuremberg, 91054 Erlangen, Germany.
Hagen LoertzerWestpfalz-Klinikum, Clinic of Urology and Paediatric Urology, 67655 Kaiserslautern, Germany.
Heiko WunderlichSt. Georg Klinikum, Clinic of Urology and Paediatric Urology, 99817 Eisenach, Germany.
Rainer M BohleInstitute of Pathology, Saarland University Medical Centre, 66421 Homburg, Germany.
Michael StöckleDepartment of Urology and Paediatric Urology, Saarland University, 66421 Homburg, Germany.
Vsevolod Borisovich MatveevDepartment of Urology, Federal State Budgetary Institution "N.N. Blokhin National Medical Research Center of Oncology" of the Ministry of Health of the Russian Federation, 115478 Moscow, Russia.ORCID 0000-0001-7748-9527
Arndt HartmannInstitute of Pathology, University Erlangen-Nuremberg, 91054 Erlangen, Germany.
Kerstin JunkerDepartment of Urology and Paediatric Urology, Saarland University, 66421 Homburg, Germany.ORCID 0000-0002-0873-8128

Funding

Universität des Saarlandes HOMFOR
6 · The paper itself

Abstract

Although microRNAs are described as promising biomarkers in many tumor types, little is known about their role in PSCC. Thus, we attempted to identify miRNAs involved in tumor development and metastasis in distinct histological subtypes considering the impact of HPV infection. In a first step, microarray analyses were performed on RNA from formalin-fixed, paraffin-embedded tumor (22), and normal (8) tissue samples. Microarray data were validated for selected miRNAs by qRT-PCR on an enlarged cohort, including 27 tumor and 18 normal tissues. We found 876 significantly differentially expressed miRNAs (

Indexed as

HPVmicroarraymiRNAPSCC

Identifiers

PMID33807023
PMCPMC8004785

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.