ReviewGeriatrics (Basel, Switzerland)2021
Deterioration, Compensation and Motor Control Processes in Healthy Aging, Mild Cognitive Impairment and Alzheimer's Disease.
Review in Geriatrics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07392840 (Postoperative Delayed Neurocognitive Recovery in Elderly Patients Undergoing Spinal Anesthesia), which is not on this map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Postoperative Delayed Neurocognitive Recovery in Elderly Patients Undergoing Spinal Anesthesia: Assessment of Its Prevalence and Correlation With Preoperative Sleep Disorders and Melanin Concentrating Hormone.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effects of swimming on cognitive and health outcomes in older adults and insights into participation facilitators and barriers: a systematic review.Frontiers in medicine · 2026Pooled it
- Behavioral and Neuroimaging Research on Developmental Coordination Disorder (DCD): A Combined Systematic Review and Meta-Analysis of Recent Findings.Frontiers in psychology · 2022Pooled it
- Effects of aging on transmission from Ia afferents to α-motoneurons and presynaptic mechanisms across muscle lengths and contraction types.GeroScience · 2026Article
- Article
- Quantifying the added value of foot-controlled force variables in predicting mild cognitive impairment.Scientific reports · 2026Article
- Article
- Comparing arm to whole-body motor control disambiguates age-related deterioration from compensation.Frontiers in aging · 2026Article
- Sleep quality metrics combined with virtual reality motion parameters enhance early detection of mild cognitive impairment.Frontiers in psychiatry · 2026Article
- Physical exercise mitigates motor and muscular deficits in the 3xTg-AD model of Alzheimer's disease.Frontiers in aging neuroscience · 2026Article
- Cognitive Impairment Is Associated with Disrupted Motor Planning in Older Adults.Neuro-degenerative diseases · 2026Article
- Presence of chronic morbidities alters skeletal muscle health and amino acid kinetics in mild cognitive impairment.Journal of Alzheimer's disease : JAD · 2025Article
- Anticipatory reaching motor behavior characterizes patients within the Alzheimer's disease continuum in a virtual reality environment.Alzheimer's research & therapy · 2025Article
- Sensory profiles in older adults with orthopedic conditions during quiet stance: a cross-sectional study.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2025Article
- The balance stabilising benefit of social touch: Influence of an individual's age and the partner's relative body characteristics.PloS one · 2025Article
- INTegRated InterveNtion of pSychogerIatric Care: real-world application and implementation of an advanced integrated telehealth system incorporating machine learning.Frontiers in psychology · 2025Article
- Force Fluctuations During Role-Differentiated Bimanual Movements Reflect Cognitive Impairments in Older Adults: A Cohort Sequential Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Modulation of movement-related oscillatory signatures by cognitive interference in healthy aging.GeroScience · 2024Article
- The tool effect is lower in older adults with or without cognitive impairments than in young adults.Psychological research · 2024Article
- Dendrobine Ameliorates Alzheimer's Disease-like Pathology and Cognitive Decline in 3 × Tg-AD Mice.Brain sciences · 2024Article
- Brain structure and phenotypic profile of superagers compared with age-matched older adults: a longitudinal analysis from the Vallecas Project.The lancet. Healthy longevity · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aging is associated with modifications of several brain structures and functions. These modifications then manifest as modified behaviors. It has been proposed that some brain function modifications may compensate for some other deteriorated ones, thus maintaining behavioral performance. Through the concept of compensation versus deterioration, this article reviews the literature on motor function in healthy and pathological aging. We first highlight mechanistic studies that used paradigms, allowing us to identify precise compensation mechanisms in healthy aging. Subsequently, we review studies investigating motor function in two often-associated neurological conditions, i.e., mild cognitive impairment and Alzheimer's disease. We point out the need to expand the knowledge gained from descriptive studies with studies targeting specific motor control processes. Teasing apart deteriorated versus compensating processes represents precious knowledge that could significantly improve the prevention and rehabilitation of age-related loss of mobility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.