Evidence map›Paper›PMID 33806892›Full record

ArticleInternational journal of molecular sciences2021

Vaporized Hydrogen Peroxide and Ozone Gas Synergistically Reduce Prion Infectivity on Stainless Steel Wire.

Hideyuki Hara, Junji Chida, Agriani Dini Pasiana, Keiji Uchiyama, Yutaka Kikuchi, Tomoko Naito, Yuichi Takahashi, Junji Yamamura, Hisashi Kuromatsu, Suehiro Sakaguchi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Recent Advances in Prion Inactivation by Plasma Sterilizer.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Hideyuki HaraDivision of Molecular Neurobiology, Institute for Enzyme Research (KOSOKEN), Tokushima University, Tokushima 770-8503, Japan.
Junji ChidaDivision of Molecular Neurobiology, Institute for Enzyme Research (KOSOKEN), Tokushima University, Tokushima 770-8503, Japan.
Agriani Dini PasianaDivision of Molecular Neurobiology, Institute for Enzyme Research (KOSOKEN), Tokushima University, Tokushima 770-8503, Japan.
Keiji UchiyamaDivision of Molecular Neurobiology, Institute for Enzyme Research (KOSOKEN), Tokushima University, Tokushima 770-8503, Japan.
Yutaka KikuchiDepartment of Nutrition, Faculty of Healthcare Sciences, Chiba Prefectural University of Health Sciences, Chiba 261-0014, Japan.
Tomoko NaitoRD Center, Miura Corporation, Ehime 799-2651, Japan.
Yuichi TakahashiRD Center, Miura Corporation, Ehime 799-2651, Japan.
Junji YamamuraEnvironment & Clean Group, Strategy Development Department, Industrial Systems & General-Purpose Machinery Business Area, IHI Corporation, Tokyo 135-8710, Japan.
Hisashi KuromatsuEnvironment & Clean Group, Strategy Development Department, Industrial Systems & General-Purpose Machinery Business Area, IHI Corporation, Tokyo 135-8710, Japan.
Suehiro SakaguchiDivision of Molecular Neurobiology, Institute for Enzyme Research (KOSOKEN), Tokushima University, Tokushima 770-8503, Japan.
Tokushima University · JPIHI Corporation (Japan) · JPChiba Prefectural University of Health Sciences · JP

Funding

IHI CorporationJapan Agency for Medical Research and Development JP19ak0101074Japan Society for the Promotion of Science 18K07499Japan Society for the Promotion of Science 19H03548Miura Corporation
6 · The paper itself

Abstract

Prions are infectious agents causing prion diseases, which include Creutzfeldt-Jakob disease (CJD) in humans. Several cases have been reported to be transmitted through medical instruments that were used for preclinical CJD patients, raising public health concerns on iatrogenic transmissions of the disease. Since preclinical CJD patients are currently difficult to identify, medical instruments need to be adequately sterilized so as not to transmit the disease. In this study, we investigated the sterilizing activity of two oxidizing agents, ozone gas and vaporized hydrogen peroxide, against prions fixed on stainless steel wires using a mouse bioassay. Mice intracerebrally implanted with prion-contaminated stainless steel wires treated with ozone gas or vaporized hydrogen peroxide developed prion disease later than those implanted with control prion-contaminated stainless steel wires, indicating that ozone gas and vaporized hydrogen peroxide could reduce prion infectivity on wires. Incubation times were further elongated in mice implanted with prion-contaminated stainless steel wires treated with ozone gas-mixed vaporized hydrogen peroxide, indicating that ozone gas mixed with vaporized hydrogen peroxide reduces prions on these wires more potently than ozone gas or vaporized hydrogen peroxide. These results suggest that ozone gas mixed with vaporized hydrogen peroxide might be more useful for prion sterilization than ozone gas or vaporized hydrogen peroxide alone.

Indexed as

PrionsStainless SteelAnimalsBrainDisease Models, AnimalDose-Response Relationship, DrugHydrogen PeroxideMiceOzonePrion DiseasesPrPC ProteinsHydrogen PeroxideOzonePrionsPrPC ProteinsStainless SteelCreutzfeldt–Jakob diseasehydrogen peroxide gasozone gasprionprion disease

Identifiers

PMID33806892
PMCPMC8005173
OpenAlexW3136052983

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.