Evidence map›Paper›PMID 33806624›Full record

ReviewMicroorganisms2021

SARS-CoV-2 Disease Adjuvant Therapies and Supplements Breakthrough for the Infection Prevention.

Alessio Danilo Inchingolo, Angelo Michele Inchingolo, Ioana Roxana Bordea, Giuseppina Malcangi, Edit Xhajanka, Antonio Scarano, Felice Lorusso, Marco Farronato, Gianluca Martino Tartaglia, Ciro Gargiulo Isacco and 8 more

Abstract readReview
In one paragraph

Review in Microorganisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Oral Lesions Following Anti-SARS-CoV-2 Vaccination: A Systematic Review.International journal of environmental research and public health · 2022
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Benefits of Natural Antioxidants on Oral Health.Antioxidants (Basel, Switzerland) · 2023
    Review
  11. Article
  12. Article
  13. Article
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  15. Review
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  17. Review
  18. Article
  19. Article
  20. Pathogenesis and Treatment of Cytokine Storm Induced by Infectious Diseases.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Alessio Danilo InchingoloDepartment of Interdisciplinary Medicine, University of Medicine Aldo Moro, 70124 Bari, Italy.
Angelo Michele InchingoloDepartment of Interdisciplinary Medicine, University of Medicine Aldo Moro, 70124 Bari, Italy.
Ioana Roxana BordeaDepartment of Oral Rehabilitation, Faculty of Dentistry, Iuliu Hațieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.ORCID 0000-0001-7166-9949
Giuseppina MalcangiDepartment of Interdisciplinary Medicine, University of Medicine Aldo Moro, 70124 Bari, Italy.
Edit XhajankaDental Prosthesis Department, Medical University of Tirana, UMT, Rruga e Dibrës, 1001 Tirana, Albania.
Antonio ScaranoDepartment of Innovative Technologies in Medicine and Dentistry, University of Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0003-1374-6146
Felice LorussoDepartment of Innovative Technologies in Medicine and Dentistry, University of Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0002-2660-9231
Marco FarronatoDepartment of Biomedical, Surgical and Dental Sciences, School of Dentistry, University of Milan, UOC Maxillo-Facial Surgery and Dentistry, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, 20100 Milan, Italy.ORCID 0000-0002-6209-9873
Gianluca Martino TartagliaDepartment of Biomedical, Surgical and Dental Sciences, School of Dentistry, University of Milan, UOC Maxillo-Facial Surgery and Dentistry, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, 20100 Milan, Italy.
Ciro Gargiulo IsaccoDepartment of Interdisciplinary Medicine, University of Medicine Aldo Moro, 70124 Bari, Italy.
Grazia MarinelliDepartment of Interdisciplinary Medicine, University of Medicine Aldo Moro, 70124 Bari, Italy.
Maria Teresa D'OriaDepartment of Interdisciplinary Medicine, University of Medicine Aldo Moro, 70124 Bari, Italy.
Denisa HazballaDepartment of Interdisciplinary Medicine, University of Medicine Aldo Moro, 70124 Bari, Italy.
Luigi SantacroceDepartment of Interdisciplinary Medicine, University of Medicine Aldo Moro, 70124 Bari, Italy.ORCID 0000-0001-5671-8124
Andrea BalliniDepartment of Biosciences, Biotechnologies and Biopharmaceutics, Campus Universitario, University of Bari, 70125 Bari, Italy.ORCID 0000-0001-8758-1415
Maria ContaldoMultidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania Luigi Vanvitelli, Via Luigi de Crecchio, 6, 80138 Naples, Italy.ORCID 0000-0002-4773-6694
Francesco InchingoloDepartment of Interdisciplinary Medicine, University of Medicine Aldo Moro, 70124 Bari, Italy.
Gianna DipalmaDepartment of Interdisciplinary Medicine, University of Medicine Aldo Moro, 70124 Bari, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is a high-risk viral agent involved in the recent pandemic stated worldwide by the World Health Organization. The infection is correlated to a severe systemic and respiratory disease in many cases, which is clinically treated with a multi-drug pharmacological approach. The purpose of this investigation was to evaluate through a literature overview the effect of adjuvant therapies and supplements for the SARS-CoV-2 infection. The research has analyzed the advantage of the EK1C4, by also assessing the studies on the resveratrol, vitamin D, and melatonin as adjuvant supplements for long hauler patients' prognosis. The evaluated substances reported important benefits for the improvement of the immune system and as a potential inhibitor molecules against SARS-CoV-2, highlighting the use of sartans as therapy. The adjuvant supplements seem to create an advantage for the healing of the long hauler patients affected by chronic symptoms of constant chest and heart pain, intestinal disorders, headache, difficulty concentrating, memory loss, and tachycardia.

Indexed as

COVID-19cytokine storm syndromeendovir stop sprayfurinmicrobiomeoral mucosapandemicsresveratrolSARS-CoV-2vaccines

Identifiers

PMID33806624
PMCPMC7999785

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.