Evidence map›Paper›PMID 33806565›Full record

ArticleInternational journal of molecular sciences2021

Optic Nerve Head and Retinal Abnormalities Associated with Congenital Fibrosis of the Extraocular Muscles.

Mervyn G Thomas, Gail D E Maconachie, Helen J Kuht, Wai-Man Chan, Viral Sheth, Michael Hisaund, Rebecca J McLean, Brenda Barry, Bashir Al-Diri, Frank A Proudlock and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Genes · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Mervyn G ThomasThe University of Leicester Ulverscroft Eye Unit, Department of Neuroscience, Psychology and Behaviour, University of Leicester, RKCSB, PO Box 65, Leicester LE2 7LX, UK.ORCID 0000-0002-4630-1234
Gail D E MaconachieThe University of Leicester Ulverscroft Eye Unit, Department of Neuroscience, Psychology and Behaviour, University of Leicester, RKCSB, PO Box 65, Leicester LE2 7LX, UK.ORCID 0000-0001-9131-3480
Helen J KuhtThe University of Leicester Ulverscroft Eye Unit, Department of Neuroscience, Psychology and Behaviour, University of Leicester, RKCSB, PO Box 65, Leicester LE2 7LX, UK.ORCID 0000-0002-7681-3062
Wai-Man ChanDepartment of Neurology, Boston Children's Hospital, Boston, MA 02115, USA.
Viral ShethThe University of Leicester Ulverscroft Eye Unit, Department of Neuroscience, Psychology and Behaviour, University of Leicester, RKCSB, PO Box 65, Leicester LE2 7LX, UK.
Michael HisaundThe University of Leicester Ulverscroft Eye Unit, Department of Neuroscience, Psychology and Behaviour, University of Leicester, RKCSB, PO Box 65, Leicester LE2 7LX, UK.
Rebecca J McLeanThe University of Leicester Ulverscroft Eye Unit, Department of Neuroscience, Psychology and Behaviour, University of Leicester, RKCSB, PO Box 65, Leicester LE2 7LX, UK.
Brenda BarryDepartment of Neurology, Boston Children's Hospital, Boston, MA 02115, USA.
Bashir Al-DiriBrayford Pool Campus, School of Computer Science, University of Lincoln, Lincoln LN6 7TS, UK.ORCID 0000-0002-9526-9058
Frank A ProudlockThe University of Leicester Ulverscroft Eye Unit, Department of Neuroscience, Psychology and Behaviour, University of Leicester, RKCSB, PO Box 65, Leicester LE2 7LX, UK.
Zhanhan TuThe University of Leicester Ulverscroft Eye Unit, Department of Neuroscience, Psychology and Behaviour, University of Leicester, RKCSB, PO Box 65, Leicester LE2 7LX, UK.
Elizabeth C EngleDepartment of Neurology, Boston Children's Hospital, Boston, MA 02115, USA.ORCID 0000-0001-8194-7738
Irene GottlobThe University of Leicester Ulverscroft Eye Unit, Department of Neuroscience, Psychology and Behaviour, University of Leicester, RKCSB, PO Box 65, Leicester LE2 7LX, UK.
University of Leicester · GBBoston Children's Hospital · USBroad Institute · USUniversity of Lincoln · GB

Funding

Mouse Neurodevelopmental Behavior CoreU54HD090255 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI SAHIN, MUSTAFA · 2016 to 2020
$5.2M
Medical Research Council MC_PC_17171Medical Research Council MR/J004189/1Medical Research Council MR/J004189/1, MRC/N004566/1 and MC_PC_17171NICHD NIH HHS U54 HD090255
6 · The paper itself

Abstract

Congenital fibrosis of the extraocular muscles (CFEOM) is a congenital cranial dysinnervation disorder caused by developmental abnormalities affecting cranial nerves/nuclei innervating the extraocular muscles. Autosomal dominant CFEOM arises from heterozygous missense mutations of

Indexed as

AdultCongenital Cranial Dysinnervation DisordersCranial NervesFemaleFibrosisHumansMaleMutation, MissenseOculomotor MusclesOphthalmoplegiaOptic DiskOptic NervePhenotypeRetinaRetinal Ganglion CellsTomography, Optical Coherencecongenital cranial dysinnervation disorderscongenital fibrosis of extraocular musclesdevelopmentoptical coherence tomographyoptic nerve hypoplasiaretinal ganglion cells

Identifiers

PMID33806565
PMCPMC7961960
OpenAlexW3133508178

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.