ReviewPathogens (Basel, Switzerland)2021
The Association between Vaginal Dysbiosis and Reproductive Outcomes in Sub-Fertile Women Undergoing IVF-Treatment: A Systematic PRISMA Review and Meta-Analysis.
Review in Pathogens (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Potential Role of Prebiotics and Probiotics on Oocyte Quality, Embryo Development, Endometrial Health, and Fertility Outcomes in Assisted Reproductive Technologies.Probiotics and antimicrobial proteins · 2026Review
- Quantitative determination of vaginal diamines as a biomarker for vaginal dysbiosis and IVF-ET outcome.Reproductive biology and endocrinology : RB&E · 2026Article
- Vaginal Nugent Lactobacillus morphotype score and endometrial pathogen detection: a two-centre retrospective study.Frontiers in endocrinology · 2026Observational
- Vaginal Microbiome and Its Relationship with Assisted Reproduction: A Systematic Review and Meta-Analysis.Life (Basel, Switzerland) · 2025Review
- Vaginal microbiome and recurrent pregnancy loss.Infection and immunity · 2025Review
- Remote BV Management via Metagenomic Vaginal Microbiome Testing and Telemedicine.Microorganisms · 2025Article
- All Properties of Infertility Microbiome in a Review Article.Journal of clinical laboratory analysis · 2025Review
- Understanding the Burden and Management of Urinary Tract Infections in Women.Diseases (Basel, Switzerland) · 2025Review
- A Metagenomics Pipeline to Characterize Self-Collected Vaginal Microbiome Samples.Diagnostics (Basel, Switzerland) · 2024Article
- Testing on bacterial vaginosis in a subfertile population and time to pregnancy: a prospective cohort study.Archives of gynecology and obstetrics · 2024Article
- Unlocking the Uterine Code: Microbiota, Immune Cells, and Therapy for Recurrent Reproductive Failure.Microorganisms · 2024Article
- Bacterial vaginosis in a subfertile population undergoing fertility treatments: a prospective cohort study.Journal of assisted reproduction and genetics · 2024Observational
- Clinical Relevance of Vaginal and Endometrial Microbiome Investigation in Women with Repeated Implantation Failure and Recurrent Pregnancy Loss.International journal of molecular sciences · 2024Review
- Cervicovaginal and gastrointestinal microbiomes in gynecological cancers and their roles in therapeutic intervention.Frontiers in microbiology · 2024Review
- Vaginal Microbiota Molecular Profiling in Women with Bacterial Vaginosis: A Novel Diagnostic Tool.International journal of molecular sciences · 2023Article
- Lactobacilli and Their Probiotic Effects in the Vagina of Reproductive Age Women.Microorganisms · 2023Review
- Endometrial Dysbiosis Is Related to Inflammatory Factors in Women with Repeated Implantation Failure: A Pilot Study.Journal of clinical medicine · 2022Article
- Identification of vaginal microbiome associated with IVF pregnancy.Scientific reports · 2022Article
- The impact of the female genital tract microbiome in women health and reproduction: a review.Journal of assisted reproduction and genetics · 2021Review
- Bacterial vaginosis: drivers of recurrence and challenges and opportunities in partner treatment.BMC medicine · 2021Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent advances in molecular microbiology have enabled refined studies of the genital tract microbiota. This constitutes the basis of the present updated systematic review and meta-analysis which investigate vaginal dysbiosis (VD) as defined by either microscopy (e.g., Nugent score for bacterial vaginosis) or molecular methods (qPCR and Next Generation Sequencing) to evaluate the impact of VD on the reproductive outcomes in women undergoing IVF-treatment. A total of 17 studies were included, comprising 3543 patients and with a VD prevalence of 18% (95%CI 17-19). Across all methods, VD is a significant risk factor for early pregnancy loss in IVF (Relative risk (RR) = 1.71 95%CI 1.29-2.27). Moreover, a predefined sub-analysis of studies using molecular methods for VD diagnosis showed a significant reduction in the clinical pregnancy rate when compared to normal vaginal microbiota patients (RR = 0.55 95%CI 0.32-0.93). However, regardless of diagnostic methodology, VD did not significantly influence live birth rate (LBR). In conclusion, molecular tools have provided a more detailed insight into the vaginal microbiota, which may be the reason for the increased adverse effect estimates in IVF patients with molecularly defined VD. However, the quality of evidence was very low across all outcomes according to GRADE and thus, more studies are warranted to understand the impact of VD in IVF.
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