Evidence map›Paper›PMID 33806316›Full record

ArticleCancers2021

Pancreatic Cancers with High Grade Tumor Budding Exhibit Hallmarks of Diminished Anti-Tumor Immunity.

Hassan Sadozai, Animesh Acharjee, Thomas Gruber, Beat Gloor, Eva Karamitopoulou

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Hassan SadozaiCenter for Sport, Exercise and Life Sciences, Coventry University, Coventry CV1 5FB, UK.ORCID 0000-0002-9003-9691
Animesh AcharjeeInstitute of Cancer and Genomic Sciences, Centre for Computational Biology, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK.ORCID 0000-0003-2735-7010
Thomas GruberIndependent Scholar, NCIS-National Coalition of Independent Scholars, CH-3930 Visp, Switzerland.
Beat GloorDepartment of Visceral Surgery, Insel University Hospital, University of Bern, CH-3010 Bern, Switzerland.
Eva KaramitopoulouPancreatic Cancer Research Group, Institute of Pathology, University of Bern, Murtenstrasse 31, CH-3008 Bern, Switzerland.
University of Bern · CHCoventry University · GBUniversity Hospitals Birmingham NHS Foundation Trust · GB

Funding

To A.A. National Institute for Health Research (NIHR) Surgical Reconstruction and Microbiology Research Centre (SRMRC), Birmingham, UK NATo E.K. Foundation for Clinical-Experimental Tumor-Research, Switzerland NA
6 · The paper itself

Abstract

Tumor budding is associated with epithelial-mesenchymal transition and diminished survival in a number of cancer types including pancreatic ductal adenocarcinoma (PDAC). In this study, we dissect the immune landscapes of patients with high grade versus low grade tumor budding to determine the features associated with immune escape and disease progression in pancreatic cancer. We performed immunohistochemistry-based quantification of tumor-infiltrating leukocytes and tumor bud assessment in a cohort of

Indexed as

gene signatureM1/M2 macrophagespancreatic ductal adenocarcinoma (PDAC)T cell-enrichedT lymphocytestumor budding

Identifiers

PMID33806316
PMCPMC7961597
OpenAlexW3135058988

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.