Evidence map›Paper›PMID 33806003›Full record

ReviewAntibiotics (Basel, Switzerland)2021

Efficacy of Toluidine Blue-Mediated Antimicrobial Photodynamic Therapy on

Rafał Wiench, Dariusz Skaba, Jacek Matys, Kinga Grzech-Leśniak

Open access · goldAbstract readReview
In one paragraph

Review in Antibiotics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 2 pooled it
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Photodynamic Therapy Modulates pri-miRNA Expression inCurrent issues in molecular biology · 2025
    Article
  5. Article
  6. The Prevalence and Drug Susceptibility ofAntibiotics (Basel, Switzerland) · 2025
    Article
  7. In Vitro Evaluation ofInternational journal of molecular sciences · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. A protocol for an overview of systematic reviews to map photodynamic inactivation evidence in different dental specialties.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2024
    Article
  17. Article
  18. Review
  19. The Impact of Hydrogen Peroxide (HJournal of clinical medicine · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Rafał WienchDepartment of Periodontal Diseases and Oral Mucosa Diseases, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland.ORCID 0000-0001-5673-7413
Dariusz SkabaDepartment of Periodontal Diseases and Oral Mucosa Diseases, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland.ORCID 0000-0001-8732-251X
Jacek MatysLaser Laboratory Dental Surgery Department, Medical University of Wroclaw, 50-425 Wroclaw, Poland.ORCID 0000-0002-3801-0218
Kinga Grzech-LeśniakLaser Laboratory Dental Surgery Department, Medical University of Wroclaw, 50-425 Wroclaw, Poland.ORCID 0000-0002-5700-4577
Medical University of Silesia · PLUniversity of Wrocław · PLVirginia Commonwealth University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The effectiveness of antimicrobial photodynamic therapy (aPDT) in the treatment of oral yeast infections was examined many times in recent years. The authors of this review tried to address the question: "Should TBO (toluidine blue ortho)-mediated aPDT be considered a possible alternative treatment for oral candidiasis?". PubMed/Medline and the Cochrane Central Register of Controlled Trials (CEN-TRAL) databases were searched from 1997 up to the 27th of October 2020 using a combination of the following keywords: (Candida OR Candidiasis oral OR Candidosis oral OR denture stomatitis) AND (toluidine blue OR photodynamic therapy OR aPDT OR photodynamic antimicrobial chemotherapy OR PACT OR photodynamic inactivation OR PDI). Animal studies or in vitro studies involving

Indexed as

aPDTCandidadiode laseroral candidiasisoral microbiomeplanktonic cells

Identifiers

PMID33806003
PMCPMC8064486
OpenAlexW3138443560

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.