Evidence map›Paper›PMID 33805784›Full record

ArticleInternational journal of molecular sciences2021

Moscatilin Inhibits Metastatic Behavior of Human Hepatocellular Carcinoma Cells: A Crucial Role of uPA Suppression via Akt/NF-κB-Dependent Pathway.

Chen-Lin Yu, Meng-Shih Weng, Wei-Cheng Chen, Kai-Ting Chien, Chih-Wen Chi, Ching-Hu Chung, Chia-Wen Huang, Po-Chuan Wang, Chien-Chih Chen, An-Chi Tsai and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
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  5. Review
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  7. Recent Research Progress on Natural Stilbenes inMolecules (Basel, Switzerland) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Chen-Lin YuInstitute of Biomedical Sciences, MacKay Medical College, New Taipei City 252, Taiwan.
Meng-Shih WengDepartment of Nutritional Science, Fu Jen Catholic University, New Taipei City 252, Taiwan.
Wei-Cheng ChenDepartment of Medicine, MacKay Medical College, New Taipei City 252, Taiwan.
Kai-Ting ChienDepartment of Orthopedic Surgery, MacKay Memorial Hospital, Taipei 104, Taiwan.
Chih-Wen ChiDepartment of Medical Research, MacKay Memorial Hospital, New Taipei City 252, Taiwan.
Ching-Hu ChungDepartment of Medicine, MacKay Medical College, New Taipei City 252, Taiwan.ORCID 0000-0002-3096-8974
Chia-Wen HuangInstitute of Biomedical Sciences, MacKay Medical College, New Taipei City 252, Taiwan.
Po-Chuan WangDepartment of Gastroenterology, Hsinchu MacKay Memorial Hospital, Hsinchu City 300, Taiwan.
Chien-Chih ChenNational Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 104, Taiwan.
An-Chi TsaiPharmacological Institutes, College of Medicine, National Taiwan University, Taipei 104, Taiwan.
Shih-Chia LiuDepartment of Orthopedic Surgery, MacKay Memorial Hospital, Taipei 104, Taiwan.
Shih-Wei WangInstitute of Biomedical Sciences, MacKay Medical College, New Taipei City 252, Taiwan.ORCID 0000-0001-7522-6352
Mackay Memorial Hospital · TWMackay Medical University · TWFu Jen Catholic University · TWKaohsiung Medical University · TWNational Research Institute of Chinese Medicine · TWNational Taiwan University · TW

Funding

Ministry of Science and Technology, Taiwan MOST 109-2628-B-715-001
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) frequently shows early invasion into blood vessels as well as intrahepatic metastasis. Innovations of novel small-molecule agents to block HCC invasion and subsequent metastasis are urgently needed. Moscatilin is a bibenzyl derivative extracted from the stems of a traditional Chinese medicine, orchid

Indexed as

AnimalsAntineoplastic Agents, PhytogenicBenzyl CompoundsCell Line, TumorCell MovementCell ProliferationChick EmbryoChorioallantoic MembraneEukaryotic Initiation Factor-4EGene Expression Regulation, NeoplasticHepatocytesHumansMatrix Metalloproteinase 2Matrix Metalloproteinase 9Neovascularization, PathologicNF-kappa BAntineoplastic Agents, PhytogenicBenzyl CompoundsdendrophenolEukaryotic Initiation Factor-4EMatrix Metalloproteinase 2Matrix Metalloproteinase 9MMP2 protein, humanMMP9 protein, humanMTOR protein, humanNF-kappa BProto-Oncogene Proteins c-aktRibosomal Protein S6 Kinases, 70-kDaTOR Serine-Threonine KinasesUrokinase-Type Plasminogen Activatorhepatocellular carcinoma (HCC)metastasismosatilinurokinase plasminogen activator (uPA)

Identifiers

PMID33805784
PMCPMC8002083
OpenAlexW3137932256

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.