Evidence map›Paper›PMID 33805767›Full record

ReviewInternational journal of molecular sciences2021

The Importance of Therapeutically Targeting the Binary Toxin from

Dinendra L Abeyawardhane, Raquel Godoy-Ruiz, Kaylin A Adipietro, Kristen M Varney, Richard R Rustandi, Edwin Pozharski, David J Weber

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. AgainstToxins · 2025
    Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Cytotoxic synergism ofWorld journal of gastroenterology · 2023
    Review
  9. Review
  10. An Update onToxins · 2022
    Review
  11. Article
  12. The Binary Toxin ofFrontiers in microbiology · 2021
    Article
  13. Invisible steps for a global endemy: molecular strategies adopted byTherapeutic advances in gastroenterology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Dinendra L AbeyawardhaneDepartment of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Raquel Godoy-RuizDepartment of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Kaylin A AdipietroDepartment of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Kristen M VarneyDepartment of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Richard R RustandiMerck & Co., Inc., Kenilworth, NJ 07033, USA.
Edwin PozharskiDepartment of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0001-7012-5376
David J WeberDepartment of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0002-8824-1110
University of Maryland, Baltimore · USMerck & Co., Inc., Rahway, NJ, USA (United States) · US

Funding

Structure-based targeting of the C. difficile toxin (CDT) from hypervirulent bacterial strainsR56AI152397 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI DES GEORGES, AMEDEE, WEBER, DAVID JOSEPH · 2021 to 2021
$522k
NIAID NIH HHS R56 AI152397
6 · The paper itself

Abstract

Novel therapeutics are needed to treat pathologies associated with the

Indexed as

Actin CytoskeletonActinsADP-RibosylationAnti-Bacterial AgentsBacterial ProteinsBacterial ToxinsBinding SitesClostridioides difficileCross InfectionEndocytosisEnterocolitis, PseudomembranousEnterotoxinsEpithelial CellsHumansModels, MolecularProtein BindingActinsAnti-Bacterial AgentsBacterial ProteinsBacterial ToxinsEnterotoxinstcdA protein, Clostridium difficiletoxB protein, Clostridium difficilebinary toxinCDTCDTaCDTbClostridioides difficileinfectious diseaseprotein structural biology

Identifiers

PMID33805767
PMCPMC8001090
OpenAlexW3136831148

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.