Evidence map›Paper›PMID 33805761›Full record

ReviewCells2021

The Pseudo-Circular Genomes of Flaviviruses: Structures, Mechanisms, and Functions of Circularization.

Louis De Falco, Nelly M Silva, Nuno C Santos, Roland G Huber, Ivo C Martins

Open access · goldAbstract readReview
In one paragraph

Review in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Zika Virus: A Tale of Two Lineages.Pathogens (Basel, Switzerland) · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Dengue Virus Capsid Protein Facilitates Genome Compaction and Packaging.International journal of molecular sciences · 2023
    Article
  9. Review
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Louis De FalcoBioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street, Matrix #07-01, Singapore 138671, Singapore.ORCID 0000-0003-1874-1838
Nelly M SilvaInstituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisbon, Portugal.
Nuno C SantosInstituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisbon, Portugal.ORCID 0000-0002-0580-0475
Roland G HuberBioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street, Matrix #07-01, Singapore 138671, Singapore.ORCID 0000-0001-5093-5988
Ivo C MartinsInstituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisbon, Portugal.ORCID 0000-0002-9284-8599
University of Lisbon · PTAgency for Science, Technology and Research · SG

Funding

Fundação Calouste Gulbenkian Science Frontiers Research Prize 2010Fundação para a Ciência e a Tecnologia FCT-MCTES program "Concurso de Estímulo ao Emprego Científico" (CEECIND/01670/2017).Fundação para a Ciência e a Tecnologia SFRH/BD/144585/2019
6 · The paper itself

Abstract

The circularization of viral genomes fulfills various functions, from evading host defense mechanisms to promoting specific replication and translation patterns supporting viral proliferation. Here, we describe the genomic structures and associated host factors important for flaviviruses genome circularization and summarize their functional roles. Flaviviruses are relatively small, single-stranded, positive-sense RNA viruses with genomes of approximately 11 kb in length. These genomes contain motifs at their 5' and 3' ends, as well as in other regions, that are involved in circularization. These motifs are highly conserved throughout the

Indexed as

FlavivirusGenome, ViralHumansVirus Replicationcircular genomescircular RNAflavivirusRNA structurevirus genomes

Identifiers

PMID33805761
PMCPMC7999817
OpenAlexW3137296388

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.