Evidence map›Paper›PMID 33805723›Full record

ArticlePolymers2021

Noninvasive Tracking of mPEG-poly(Ala) Hydrogel-Embedded MIN6 Cells after Subcutaneous Transplantation in Mice.

Jyuhn-Huarng Juang, Hsiu-Chao Lin, Chen-Yi Chen, Chen-Wei Kao, Chen-Ling Chen, Shu-Ting Wu, Sung-Han Lin, Chia-Rui Shen, Jiun-Jie Wang, Zei-Tsan Tsai and 1 more

Open access · goldAbstract read

PubMed Full text at PMC Publisher

In one paragraph

Article in Polymers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it

0cells of the map it votes in

5citing papers in PubMed

1.3field-weighted citation impact, top 21% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

In Vivo Imaging of Immune Rejection of MIN6 Cells Transplanted in C3H Mice.Cells · 2024
Article
The Image-Histology Correlation of Subcutaneous mPEG-poly(Ala) Hydrogel-Embedded MIN6 Cell Grafts in Nude Mice.Polymers · 2023
Article
Magnetic Resonance Imaging of Transplanted Porcine Neonatal Pancreatic Cell Clusters Labeled with Exendin-4-Conjugated Manganese Magnetism-Engineered Iron Oxide Nanoparticles.Nanomaterials (Basel, Switzerland) · 2022
Article
Exendin-4-Conjugated Manganese Magnetism-Engineered Iron Oxide Nanoparticles as a Potential Magnetic Resonance Imaging Contrast Agent for Tracking Transplanted β-Cells.Nanomaterials (Basel, Switzerland) · 2021
Article
Two in One: Use of Divalent Manganese Ions as Both Cross-Linking and MRI Contrast Agent for Intrathecal Injection of Hydrogel-Embedded Stem Cells.Pharmaceutics · 2021
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Jyuhn-Huarng JuangDivision of Endocrinology and Metabolism, Department of Internal Medicine and Center for Tissue Engineering, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan.

Hsiu-Chao LinDepartment of Chemical Engineering, National Tsing Hua University, Hsinchu 300044, Taiwan.

Chen-Yi ChenDivision of Endocrinology and Metabolism, Department of Internal Medicine and Center for Tissue Engineering, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan.

Chen-Wei KaoDivision of Endocrinology and Metabolism, Department of Internal Medicine and Center for Tissue Engineering, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan.

Chen-Ling ChenDivision of Endocrinology and Metabolism, Department of Internal Medicine and Center for Tissue Engineering, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan.

Shu-Ting WuDepartment of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.

Sung-Han LinDepartment of Medical Imaging and Radiological Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.ORCID 0000-0003-1384-4037

Chia-Rui ShenDepartment of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.

Jiun-Jie WangDepartment of Medical Imaging and Radiological Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.

Zei-Tsan TsaiMolecular Imaging Center, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan.

I-Ming ChuDepartment of Chemical Engineering, National Tsing Hua University, Hsinchu 300044, Taiwan.

Chang Gung University · TWChang Gung Memorial Hospital · TWNational Tsing Hua University · TW

Funding

Chang Gung Memorial Hospital CMRPG3F0711-3 and CMRPG3G1961Chang Gung Memorial Hospital and National Tsing Hua University Joint Research Program CGMH-NTHU 2020 CORPG3K0031 and 109Q2513E1Chang Gung Memorial Hospital-National Tsing Hua University Joint Research Program 2019 CORPG3I0031 and 108Q2505E1

6 · The paper itself

Abstract

Recently, we demonstrated the feasibility of subcutaneous transplantation of MIN6 cells embedded in a scaffold with poly(ethylene glycol) methyl ether (mPEG)-poly(Ala) hydrogels. In this study, we further tracked these grafts using magnetic resonance (MR) and bioluminescence imaging. After being incubated overnight with chitosan-coated superparamagnetic iron oxide (CSPIO) nanoparticles and then mixed with mPEG-poly(Ala) hydrogels, MIN6 cells appeared as dark spots on MR scans. For in vivo experiments, we transfected MIN6 cells with luciferase and/or incubated them overnight with CSPIO overnight; 5 × 10

Indexed as

bioluminescence imagingmagnetic resonance imagingMIN6 cellssubcutaneous transplantationthermosensitive hydrogels

Identifiers

PMID33805723

DOI10.3390/polym13060885

PMCPMC7998640

OpenAlexW3136270178

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.