Evidence map›Paper›PMID 33805704›Full record

ArticleMolecules (Basel, Switzerland)2021

Facile Tailoring of Structures for Controlled Release of Paracetamol from Sustainable Lignin Derived Platforms.

Mario Culebras, Mahboubeh Pishnamazi, Gavin M Walker, Maurice N Collins

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Lignin, the Lignification Process, and Advanced, Lignin-Based Materials.International journal of molecular sciences · 2023
    Review
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mario CulebrasStokes Laboratories, School of Engineering, Bernal Institute and AMBER, University of Limerick, V94 T9PX Limerick, Ireland.
Mahboubeh PishnamaziPharmaceutical Centre (SSPC), University of Limerick, V94 T9PX Limerick, Ireland.
Gavin M WalkerPharmaceutical Centre (SSPC), University of Limerick, V94 T9PX Limerick, Ireland.
Maurice N CollinsStokes Laboratories, School of Engineering, Bernal Institute and AMBER, University of Limerick, V94 T9PX Limerick, Ireland.ORCID 0000-0003-2536-4508

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nowadays, sustainable materials are receiving significant attention due to the fact that they will be crucial for the development of the next generation of products and devices. In the present work, hydrogels have been successfully synthesized using lignin which is non-valorized biopolymer from the paper industry. Hydrogels were prepared via crosslinking with Poly(ethylene) glycol diglycidyl ether (PEGDGE). Different crosslinker ratios were used to determine their influence on the structural and chemical properties of the resulting hydrogels. It has been found that pore size was reduced by increasing crosslinker amount. The greater crosslinking density increased the swelling capacity of the hydrogels due to the presence of more hydrophilic groups in the hydrogel network. Paracetamol release test showed higher drug diffusion for hydrogels produced with a ratio lignin:PEGDGE 1:1. The obtained results demonstrate that the proposed approach is a promising route to utilize lignocellulose waste for producing porous materials for advanced biomedical applications in the pharmacy industry.

Indexed as

AcetaminophenBiocompatible MaterialsCross-Linking ReagentsDelayed-Action PreparationsEpoxy ResinsFreeze DryingHumansHydrogelsHydrophobic and Hydrophilic InteractionsIndustrial WasteLigninMicroscopy, Electron, ScanningMolecular StructureSpectroscopy, Fourier Transform InfraredAcetaminophenBiocompatible MaterialsCross-Linking ReagentsDelayed-Action PreparationsEpoxy ResinsHydrogelsIndustrial WasteLigninlignocelluloseQuetol 651crosslinkingdrug releasehydrogelslignin

Identifiers

PMID33805704
PMCPMC8000009

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.