ArticleNanomaterials (Basel, Switzerland)2021
Degradation Mechanism of Porous Metal-Organic Frameworks by In Situ Atomic Force Microscopy.
Article in Nanomaterials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed.
- Safety, In Vivo Fate, and Degradation of MOF Nanomedicines: Toward Translational Evaluation.Pharmaceutics · 2026Review
- Green Aerogels for Atmospheric Water Harvesting: A PRISMA-Guided Systematic Review of Bio-Derived Materials and Pathways to 2035.Polymers · 2025Review
- Direct Optical Visualization of In Situ Photodegradation Dynamics in Metal-Organic Frameworks.Chemical & biomedical imaging · 2025Article
- Iron-MOFs for Biomedical Applications.Advanced healthcare materials · 2025Review
- MOF-Enhanced Phototherapeutic Wound Dressings Against Drug-Resistant Bacteria.Advanced healthcare materials · 2025Article
- Nanoscale metal-organic frameworks for the delivery of nucleic acids to cancer cells.International journal of pharmaceutics: X · 2023Article
- The feasibility of oral targeted drug delivery: Gut immune to particulates?Acta pharmaceutica Sinica. B · 2023Review
- MIL-100(Fe) Sub-Micrometric Capsules as a Dual Drug Delivery System.International journal of molecular sciences · 2022Article
- Porous Metal-Organic Framework Nanoparticles.Nanomaterials (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
In recent years, Metal-Organic Frameworks (MOFs) have attracted a growing interest for biomedical applications. The design of MOFs should take into consideration the subtle balance between stability and biodegradability. However, only few studies have focused on the MOFs' stability in physiological media and their degradation mechanism. Here, we investigate the degradation of mesoporous iron (III) carboxylate MOFs, which are among the most employed MOFs for drug delivery, by a set of complementary methods. In situ AFM allowed monitoring with nanoscale resolution the morphological, dimensional, and mechanical properties of a series of MOFs in phosphate buffer saline and in real time. Depending on the synthetic route, the external surface presented either well-defined crystalline planes or initial defects, which influenced the degradation mechanism of the particles. Moreover, MOF stability was investigated under different pH conditions, from acidic to neutral. Interestingly, despite pronounced erosion, especially at neutral pH, the dimensions of the crystals were unchanged. It was revealed that the external surfaces of MOF crystals rapidly respond to in situ changes of the composition of the media they are in contact with. These observations are of a crucial importance for the design of nanosized MOFs for drug delivery applications.
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Registered trials
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