Evidence map›Paper›PMID 33805588›Full record

ArticleNutrients2021

Maternal Vitamin C and Iron Intake during Pregnancy and the Risk of Islet Autoimmunity and Type 1 Diabetes in Children: A Birth Cohort Study.

Markus Mattila, Leena Hakola, Sari Niinistö, Heli Tapanainen, Hanna-Mari Takkinen, Suvi Ahonen, Jorma Ilonen, Jorma Toppari, Riitta Veijola, Mikael Knip and 1 more

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Observational
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Markus MattilaUnit of Health Sciences, Faculty of Social Sciences, Tampere University, FI-33014 Tampere, Finland.ORCID 0000-0002-7829-9474
Leena HakolaUnit of Health Sciences, Faculty of Social Sciences, Tampere University, FI-33014 Tampere, Finland.ORCID 0000-0001-7115-6035
Sari NiinistöHealth and Well-Being Promotion Unit, Finnish Institute for Health and Welfare, P.O. Box 30, FI-00271 Helsinki, Finland.
Heli TapanainenPopulation Health Unit, Finnish Institute for Health and Welfare, P.O. Box 30, FI-00271 Helsinki, Finland.
Hanna-Mari TakkinenUnit of Health Sciences, Faculty of Social Sciences, Tampere University, FI-33014 Tampere, Finland.
Suvi AhonenUnit of Health Sciences, Faculty of Social Sciences, Tampere University, FI-33014 Tampere, Finland.
Jorma IlonenImmunogenetics Laboratory, Institute of Biomedicine, University of Turku, FI-20014 Turku, Finland.ORCID 0000-0002-9973-2062
Jorma ToppariResearch Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, FI-20520 Turku, Finland.
Riitta VeijolaPEDEGO Research Unit, Department of Pediatrics, Medical Research Center, University of Oulu, P.O. Box 8000, FI-90014 Oulu, Finland.
Mikael KnipPediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, FI-00029 Helsinki, Finland.ORCID 0000-0003-0474-0033
Suvi M VirtanenUnit of Health Sciences, Faculty of Social Sciences, Tampere University, FI-33014 Tampere, Finland.
Tampere University · FIFinnish Institute for Health and Welfare · FIUniversity of Turku · FIOulu University Hospital · FIUniversity of Helsinki · FI

Funding

Competitive Research Funding of the Turku and Oulu University Hospitals; the Competitive State Research Financing of the Expert Responsibility area of Tampere University Hospital 9E082Competitive Research Funding of the Turku and Oulu University Hospitals; the Competitive State Research Financing of the Expert Responsibility area of Tampere University Hospital 9F089Competitive Research Funding of the Turku and Oulu University Hospitals; the Competitive State Research Financing of the Expert Responsibility area of Tampere University Hospital 9G087Competitive Research Funding of the Turku and Oulu University Hospitals; the Competitive State Research Financing of the Expert Responsibility area of Tampere University Hospital 9H092Competitive Research Funding of the Turku and Oulu University Hospitals; the Competitive State Research Financing of the Expert Responsibility area of Tampere University Hospital 9J147Competitive Research Funding of the Turku and Oulu University Hospitals; the Competitive State Research Financing of the Expert Responsibility area of Tampere University Hospital 9K149Competitive Research Funding of the Turku and Oulu University Hospitals; the Competitive State Research Financing of the Expert Responsibility area of Tampere University Hospital 9L117Competitive Research Funding of the Turku and Oulu University Hospitals; the Competitive State Research Financing of the Expert Responsibility area of Tampere University Hospital 9M114Competitive Research Funding of the Turku and Oulu University Hospitals; the Competitive State Research Financing of the Expert Responsibility area of Tampere University Hospital 9N086Competitive Research Funding of the Turku and Oulu University Hospitals; the Competitive State Research Financing of the Expert Responsibility area of Tampere University Hospital 9P057Competitive Research Funding of the Turku and Oulu University Hospitals; the Competitive State Research Financing of the Expert Responsibility area of Tampere University Hospital 9R055Competitive Research Funding of the Turku and Oulu University Hospitals; the Competitive State Research Financing of the Expert Responsibility area of Tampere University Hospital 9S074Competitive Research Funding of the Turku and Oulu University Hospitals; the Competitive State Research Financing of the Expert Responsibility area of Tampere University Hospital 9U065Competitive Research Funding of the Turku and Oulu University Hospitals; the Competitive State Research Financing of the Expert Responsibility area of Tampere University Hospital 9V072Competitive Research Funding of the Turku and Oulu University Hospitals; the Competitive State Research Financing of the Expert Responsibility area of Tampere University Hospital 9X062Doctoral Programme in Health Sciences, Tampere UniversityDoctoral Programs in Public Health; the Academy of Finland 126813Doctoral Programs in Public Health; the Academy of Finland 201988Doctoral Programs in Public Health; the Academy of Finland 210632Doctoral Programs in Public Health; the Academy of Finland 276475Doctoral Programs in Public Health; the Academy of Finland 63672Doctoral Programs in Public Health; the Academy of Finland 79685Doctoral Programs in Public Health; the Academy of Finland 79686Doctoral Programs in Public Health; the Academy of Finland 80846EFSD/JDRF/Lilly European Programme in Type 1 Diabetes Research;Juvenile Diabetes Research Foundation 197032Juvenile Diabetes Research Foundation 4-1998-274Juvenile Diabetes Research Foundation 4-1999-731Juvenile Diabetes Research Foundation 4-2001-435Novo Nordisk Foundation; and the European Union Biomed 2 Program BMH4-CT98-3314The Jenny and Antti Wihuri Foundation
6 · The paper itself

Abstract

Our aim was to study the associations between maternal vitamin C and iron intake during pregnancy and the offspring's risk of developing islet autoimmunity and type 1 diabetes. The study was a part of the Finnish Type 1 Diabetes Prediction and Prevention (DIPP) prospective birth cohort including children genetically at risk of type 1 diabetes born between 1997-2004. The diets of 4879 mothers in late pregnancy were assessed with a validated food frequency questionnaire. The outcomes were islet autoimmunity and type 1 diabetes. Cox proportional hazards regression analysis adjusted for energy, family history of diabetes, human leukocyte antigen (HLA) genotype and sex was used for statistical analyses. Total intake of vitamin C or iron from food and supplements was not associated with the risk of islet autoimmunity (vitamin C: HR 0.91: 95% CI (0.80, 1.03), iron: 0.98 (0.87, 1.10)) or type 1 diabetes (vitamin C: 1.01 (0.87, 1.17), iron: 0.92 (0.78, 1.08)), neither was the use of vitamin C or iron supplements associated with the outcomes. In conclusion, no association was found between maternal vitamin C or iron intake during pregnancy and the risk of islet autoimmunity or type 1 diabetes in the offspring.

Indexed as

AdultAscorbic AcidAutoimmune DiseasesChild, PreschoolDiabetes Mellitus, Type 1DietDietary SupplementsDiet SurveysFemaleFinlandGenotypeHLA AntigensHumansInfantIron, DietaryIslets of LangerhansAscorbic AcidHLA AntigensIron, Dietaryascorbic acidbirth cohortironislet autoimmunitynutritionpregnancytype 1 diabetesvitamin C

Identifiers

PMID33805588
PMCPMC8001228
OpenAlexW3138643262

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.