ReviewGenes2021
Whole-Body Regeneration in Sponges: Diversity, Fine Mechanisms, and Future Prospects.
Review in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- Rethinking Plasticity in Sponges.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2026Pooled it
- Conditional Senescence and Longevity Mechanisms in Early-Branching Metazoans: Insights fromCurrent issues in molecular biology · 2026Article
- Silicon Deficiency and the Endemic Sponge Lubomirskia baikalensis (Pallas, 1773): What Happens With Its Skeleton in Changing Environment?Journal of experimental zoology. Part A, Ecological and integrative physiology · 2026Article
- Complete ectosome formation from the choanosome during whole-body regeneration of the sponge Hymeniacidon heliophila (Wilson 1911) using an in vitro microexplant model.In vitro cellular & developmental biology. Animal · 2026Article
- Reproduction and Development in Calcareous Sponges: A Panorama of the Last Two Centuries.Molecular reproduction and development · 2026Review
- Endocytosed lipids induce cell aggregation via filopodia retraction in a close relative of animals.EMBO reports · 2026Article
- Chromosome-level genome assembly of the sponge Halisarca dujardinii.Scientific data · 2026Article
- Article
- The pathoanatomy of cancer: order in paradox.EBioMedicine · 2026Review
- DNA methylation in invertebrate genomes and cell lineage plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Macrophage-mediated nutrient recycling: evolutionary insights into the metabolic role of professional phagocytes.Frontiers in immunology · 2026Review
- Oxygen regulation in the earliest animals: spatiotemporal resolution of oxygen dynamics in single-osculumFrontiers in physiology · 2026Article
- Article
- Proteomic and transcriptomic signatures of cytoskeletal remodeling during morphogenesis in the basal metazoanFrontiers in cell and developmental biology · 2026Article
- First draft genome assembly of sponge Halisarca dujardinii reveals key components of basement membrane and broad repertoire of aggregation factors.Scientific reports · 2025Article
- From fragment to form: whole-body regeneration in a model urochordate.NPJ Regenerative medicine · 2025Review
- Microtubule organization and tubulin post-translational modifications in intact tissues and during regeneration in calcareous sponges.Cell and tissue research · 2025Article
- The divergent intron-containing actin in sponge morphogenetic processes.NAR genomics and bioinformatics · 2025Article
- Renal Intercalated Cells: Alien Cells Inside Us?Biology · 2025Review
- DNA State Influences the Uptake and Persistence of Environmental DNA by Marine Sponge Natural Samplers.Ecology and evolution · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While virtually all animals show certain abilities for regeneration after an injury, these abilities vary greatly among metazoans. Porifera (Sponges) is basal metazoans characterized by a wide variety of different regenerative processes, including whole-body regeneration (WBR). Considering phylogenetic position and unique body organization, sponges are highly promising models, as they can shed light on the origin and early evolution of regeneration in general and WBR in particular. The present review summarizes available data on the morphogenetic and cellular mechanisms accompanying different types of WBR in sponges. Sponges show a high diversity of WBR, which principally could be divided into (1) WBR from a body fragment and (2) WBR by aggregation of dissociated cells. Sponges belonging to different phylogenetic clades and even to different species and/or differing in the anatomical structure undergo different morphogeneses after similar operations. A common characteristic feature of WBR in sponges is the instability of the main body axis: a change of the organism polarity is described during all types of WBR. The cellular mechanisms of WBR are different across sponge classes, while cell dedifferentiations and transdifferentiations are involved in regeneration processes in all sponges. Data considering molecular regulation of WBR in sponges are extremely scarce. However, the possibility to achieve various types of WBR ensured by common morphogenetic and cellular basis in a single species makes sponges highly accessible for future comprehensive physiological, biochemical, and molecular studies of regeneration processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.