Evidence map›Paper›PMID 33805532›Full record

ArticleInternational journal of molecular sciences2021

NMRK2 Gene Is Upregulated in Dilated Cardiomyopathy and Required for Cardiac Function and NAD Levels during Aging.

Cynthia Tannous, Robin Deloux, Ahmed Karoui, Nathalie Mougenot, Dean Burkin, Jocelyne Blanc, Dario Coletti, Gareth Lavery, Zhenlin Li, Mathias Mericskay

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. NADCommunications biology · 2026
    Article
  3. Cellular and molecular mechanisms underlying cardiovascular aging.Cellular & molecular biology letters · 2025
    Review
  4. Review
  5. The Role of NADAmerican journal of cardiovascular drugs : drugs, devices, and other interventions · 2025
    Review
  6. Emerging interactions between mitochondria and NADTrends in endocrinology and metabolism: TEM · 2025
    Review
  7. Article
  8. NAD metabolism and heart failure: Mechanisms and therapeutic potentials.Journal of molecular and cellular cardiology · 2024
    Review
  9. Cardiac NADNature cardiovascular research · 2024
    Article
  10. Nicotinamide Mononucleotide: Research Process in Cardiovascular Diseases.International journal of molecular sciences · 2024
    Review
  11. Article
  12. Review
  13. Article
  14. NAD in pathological cardiac remodeling: Metabolic regulation and beyond.Biochimica et biophysica acta. Molecular basis of disease · 2024
    Review
  15. Article
  16. Article
  17. Circadian cardiac NADAmerican journal of physiology. Cell physiology · 2022
    Review
  18. Balancing NADCellular and molecular life sciences : CMLS · 2022
    Review
  19. Harnessing NADCurrent heart failure reports · 2022
    Review
  20. Metabolic Therapy of Heart Failure: Is There a Future for B Vitamins?International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Cynthia TannousInserm Unit UMR-S 1180 CARPAT, Faculty of Pharmacy, Université Paris-Saclay, 92296 Châtenay-Malabry, France.
Robin DelouxInserm Unit UMR-S 1180 CARPAT, Faculty of Pharmacy, Université Paris-Saclay, 92296 Châtenay-Malabry, France.ORCID 0000-0002-4601-266X
Ahmed KarouiInserm Unit UMR-S 1180 CARPAT, Faculty of Pharmacy, Université Paris-Saclay, 92296 Châtenay-Malabry, France.
Nathalie MougenotPlateau d'Expérimentation Cœur, Muscle, Vaisseaux PECMV, UMS28, Sorbonne Université, 75013 Paris, France.
Dean BurkinDepartment of Pharmacology, Reno School of Medicine, University of Nevada, Reno, NV 89102, USA.
Jocelyne BlancINSERM Unit U1164 / CNRS UMR 8256, Biologie de l'Adaptation et du Vieillissement, Institut de Biologie Paris-Seine, Sorbonne Université, 75006 Paris, France.
Dario ColettiINSERM Unit U1164 / CNRS UMR 8256, Biologie de l'Adaptation et du Vieillissement, Institut de Biologie Paris-Seine, Sorbonne Université, 75006 Paris, France.ORCID 0000-0001-7373-1953
Gareth LaveryInstitute of Metabolism and Systems Research, University of Birmingham, 2nd Floor IBR Tower, Edgbaston, Birmingham B15 2TT, UK.
Zhenlin LiINSERM Unit U1164 / CNRS UMR 8256, Biologie de l'Adaptation et du Vieillissement, Institut de Biologie Paris-Seine, Sorbonne Université, 75006 Paris, France.ORCID 0000-0002-3706-4505
Mathias MericskayInserm Unit UMR-S 1180 CARPAT, Faculty of Pharmacy, Université Paris-Saclay, 92296 Châtenay-Malabry, France.ORCID 0000-0002-6779-092X

Funding

Agence Nationale de la Recherche #ANR-17-CE17-0015-01Association Française contre les Myopathies MUSCLE-MINDS # 16282
6 · The paper itself

Abstract

Dilated cardiomyopathy (DCM) is a disease of multifactorial etiologies, the risk of which is increased by male sex and age. There are few therapeutic options for patients with DCM who would benefit from identification of common targetable pathways. We used bioinformatics to identify the

Indexed as

AgingAnimalsCardiomegalyCardiomyopathy, DilatedCytosolDisease Models, AnimalElectrocardiographyGene Expression RegulationHumansIntracellular Signaling Peptides and ProteinsLamininMiceMice, Inbred C57BLMice, KnockoutNADNiacinamideIntracellular Signaling Peptides and ProteinsLamininNADNiacinamideNMRK2 protein, humanNmrk2 protein, mousePhosphotransferases (Alcohol Group Acceptor)dilated cardiomyopathyeccentric hypertrophymuscle integrin binding proteinnicotinamide adenine dinucleotidenicotinamide riboside kinase 2pressure overload

Identifiers

PMID33805532
PMCPMC8036583

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.