Evidence map›Paper›PMID 33805516›Full record

ArticleInternational journal of molecular sciences2021

Xanthine Oxidoreductase-Mediated Superoxide Production Is Not Involved in the Age-Related Pathologies in

Shuichi Shibuya, Kenji Watanabe, Yusuke Ozawa, Takahiko Shimizu

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
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  6. Antimicrobial Properties of Colostrum and Milk.Antibiotics (Basel, Switzerland) · 2024
    Review
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  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Shuichi ShibuyaAging Stress Response Research Project Team, National Center for Geriatrics and Gerontology, Obu, Aichi 474-8511, Japan.
Kenji WatanabeAging Stress Response Research Project Team, National Center for Geriatrics and Gerontology, Obu, Aichi 474-8511, Japan.ORCID 0000-0003-1707-1676
Yusuke OzawaDepartment of Endocrinology, Hematology, and Geriatrics, Chiba University Graduate School of Medicine, Chiba, Chiba 260-8670, Japan.
Takahiko ShimizuAging Stress Response Research Project Team, National Center for Geriatrics and Gerontology, Obu, Aichi 474-8511, Japan.ORCID 0000-0002-3351-3342
Chiba University · JPNational Center for Geriatrics and Gerontology · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reactive oxygen species (ROS) metabolism is regulated by the oxygen-mediated enzyme reaction and antioxidant mechanism within cells under physiological conditions. Xanthine oxidoreductase (XOR) exhibits two inter-convertible forms (xanthine oxidase (XO) and xanthine dehydrogenase (XDH)), depending on the substrates. XO uses oxygen as a substrate and generates superoxide (O

Indexed as

AcetophenonesAgingAllopurinolAnemiaAnimalsFatty LiverMiceMice, Mutant StrainsMuscular AtrophyNADPH OxidasesSuperoxide Dismutase-1SuperoxidesXanthine DehydrogenaseAcetophenonesacetovanilloneAllopurinolNADPH OxidasesSod1 protein, mouseSuperoxide Dismutase-1SuperoxidesXanthine Dehydrogenaseagingoxidative stressSOD1superoxidexanthine oxidoreductase

Identifiers

PMID33805516
PMCPMC8037342
OpenAlexW3147715265

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.