Evidence map›Paper›PMID 33805470›Full record

ArticleMarine drugs2021

Influence of Fucoidan Extracts from Different Fucus Species on Adult Stem Cells and Molecular Mediators in In Vitro Models for Bone Formation and Vascularization.

Fanlu Wang, Yuejun Xiao, Sandesh Neupane, Signe Helle Ptak, Ramona Römer, Junyu Xiong, Julia Ohmes, Andreas Seekamp, Xavier Fretté, Susanne Alban and 1 more

Open access · goldAbstract readComparative Study
In one paragraph

Article in Marine drugs, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

  1. Fucoidan fromMarine drugs · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. The Ocean's Pharmacy: Health Discoveries in Marine Algae.Molecules (Basel, Switzerland) · 2024
    Review
  7. Arctic Edible Brown AlgaPlants (Basel, Switzerland) · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Fanlu WangExperimental Trauma Surgery, Department of Orthopedics and Trauma Surgery, University Medical Center Schleswig-Holstein, 24105 Kiel, Germany.
Yuejun XiaoExperimental Trauma Surgery, Department of Orthopedics and Trauma Surgery, University Medical Center Schleswig-Holstein, 24105 Kiel, Germany.
Sandesh NeupaneDepartment of Pharmaceutical Biology, Pharmaceutical Institute, Kiel University, 24148 Kiel, Germany.ORCID 0000-0002-5167-9848
Signe Helle PtakSDU Chemical Engineering, University of Southern Denmark, 5230 Odense, Denmark.
Ramona RömerExperimental Trauma Surgery, Department of Orthopedics and Trauma Surgery, University Medical Center Schleswig-Holstein, 24105 Kiel, Germany.
Junyu XiongExperimental Trauma Surgery, Department of Orthopedics and Trauma Surgery, University Medical Center Schleswig-Holstein, 24105 Kiel, Germany.
Julia OhmesExperimental Trauma Surgery, Department of Orthopedics and Trauma Surgery, University Medical Center Schleswig-Holstein, 24105 Kiel, Germany.
Andreas SeekampExperimental Trauma Surgery, Department of Orthopedics and Trauma Surgery, University Medical Center Schleswig-Holstein, 24105 Kiel, Germany.
Xavier FrettéSDU Chemical Engineering, University of Southern Denmark, 5230 Odense, Denmark.
Susanne AlbanDepartment of Pharmaceutical Biology, Pharmaceutical Institute, Kiel University, 24148 Kiel, Germany.ORCID 0000-0003-1993-3751
Sabine FuchsExperimental Trauma Surgery, Department of Orthopedics and Trauma Surgery, University Medical Center Schleswig-Holstein, 24105 Kiel, Germany.
University Hospital Schleswig-Holstein · DEChristian-Albrechts-Universität zu Kiel · DEUniversity of Southern Denmark · DK

Funding

Interreg FucoSan
6 · The paper itself

Abstract

Fucoidans, sulfated polysaccharides extracted from brown algae, are marine products with the potential to modulate bone formation and vascularization processes. The bioactivity and safety of fucoidans are highly associated with their chemical structure, which may vary with algae species and extraction method. Thus, in depth evaluation of fucoidan extracts in terms of endotoxin content, cytotoxicity, and their detailed molecular biological impact on the individual cell types in bone is needed. In this study, we characterized fucoidan extracts from three different

Indexed as

Angiogenesis InhibitorsAngiogenic ProteinsCell ProliferationCells, CulturedCoculture TechniquesEndothelial CellsEnergy MetabolismFucusHumansInflammation MediatorsMesenchymal Stem CellsMolecular WeightNeovascularization, PhysiologicOsteogenesisPolysaccharidesSignal TransductionAngiogenesis InhibitorsAngiogenic ProteinsfucoidanInflammation MediatorsPolysaccharidesangiogenesisbone vascularizationfucoidanmesenchymal stem cells (MSC)outgrowth endothelial cells (OEC)

Identifiers

PMID33805470
PMCPMC8066524
OpenAlexW3141944364

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.