Evidence map›Paper›PMID 33805460›Full record

ReviewJournal of clinical medicine2021

Hypoparathyroidism in Pregnancy and Lactation: Current Approach to Diagnosis and Management.

Dalal S Ali, Karel Dandurand, Aliya A Khan

Open access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Hypocalcemic Tetany Transiently "Cured" by Pregnancy: A Case Report.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Approach to the Patient: Management of Parathyroid Diseases Across Pregnancy.The Journal of clinical endocrinology and metabolism · 2023
    Article
  10. Review
  11. Article
  12. Treatment options in hypoparathyroidism.Archives of endocrinology and metabolism · 2022
    Review
  13. Subcutaneous Infusion of rhPTHJournal of the Endocrine Society · 2022
    Article
  14. Transient hypercalcemia followed by hypocalcemia in a preterm infant after maternal magnesium sulfate therapy.Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology · 2022
    Article
  15. Fetomaternal Acid-Base Balance and Electrolytes during Pregnancy.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2021
    Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Dalal S AliDivision of Endocrinology and Metabolism, McMaster University, Hamilton, ON L8S 4L8, Canada.ORCID 0000-0002-5378-5548
Karel DandurandDivision of Endocrinology and Metabolism, McMaster University, Hamilton, ON L8S 4L8, Canada.
Aliya A KhanDivision of Endocrinology and Metabolism, McMaster University, Hamilton, ON L8S 4L8, Canada.
McMaster University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHypoparathyroidism is an uncommon endocrine disorder. During pregnancy, multiple changes occur in the calcium-regulating hormones, which may affect the requirements of calcium and active vitamin D during pregnancy in patients with hypoparathyroidism. Close monitoring of serum calcium during pregnancy and lactation is ideal in order to optimize maternal and fetal outcomes. In this review, we describe calcium homeostasis during pregnancy in euparathyroid individuals and also review the diagnosis and management of hypoparathyroidism during pregnancy and lactation.

methodsWe searched the MEDLINE, CINAHL, EMBASE, and Google scholar databases from 1 January 1990 to 31 December 2020. Case reports, case series, book chapters, and clinical guidelines were included in this review.

conclusionsDuring pregnancy, rises in 1,25-dihydroxyvitamin D (1,25-(OH)2-D3) and PTH-related peptide result in suppression of PTH and enhanced calcium absorption from the bowel. In individuals with hypoparathyroidism, the requirements for calcium and active vitamin D may decrease. Close monitoring of serum calcium is advised in women with hypoparathyroidism with adjustment of the doses of calcium and active vitamin D to ensure that serum calcium is maintained in the low-normal to mid-normal reference range. Hyper- and hypocalcemia should be avoided in order to reduce the maternal and fetal complications of hypoparathyroidism during pregnancy and lactation. Standard of care therapy consisting of elemental calcium, active vitamin D, and vitamin D is safe during pregnancy.

Indexed as

active vitamin Dcalcitriolcalcium homeostasishypoparathyroidismlactationpregnancyPTH/PTHrP

Identifiers

PMID33805460
PMCPMC8038023
OpenAlexW3146989270

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.