Evidence map›Paper›PMID 33805404›Full record

ArticleViruses2021

Feasibility and Effectiveness Studies with Oral Vaccination of Free-Roaming Dogs against Rabies in Thailand.

Karoon Chanachai, Vilaiporn Wongphruksasoong, Ad Vos, Kansuda Leelahapongsathon, Ratanaporn Tangwangvivat, Onpawee Sagarasaeranee, Paisin Lekcharoen, Porathip Trinuson, Suwicha Kasemsuwan

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Feasibility of Oral Rabies Vaccination of Dogs in Mexico.Tropical medicine and infectious disease · 2025
    Article
  7. Review
  8. Article
  9. Article
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  13. Article
  14. Article
  15. Frontiers in microbiology · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Karoon ChanachaiUSAID Regional Development Mission Asia (Former at the Department of Livestock Development, Thailand), Athenee Tower, 25th Floor, 63 Wireless Road, Lumpini, Patumwan, Bangkok 10330, Thailand.
Vilaiporn WongphruksasoongDepartment of Livestock Development, Ministry of Agriculture, Ratchathewi, Bangok 10400, Thailand.
Ad VosCEVA Innovation Center GmbH, Am Pharmapark, 06861 Dessau-Rosslau, Germany.
Kansuda LeelahapongsathonFaculty of Veterinary Medicine, Kasetsart University, Kamphaeng Saen 73140, Thailand.ORCID 0000-0001-6101-5191
Ratanaporn TangwangvivatDepartment of Disease Control, Ministry of Public Health, 88/21 Tiwanon Rd., Talard-Kwan, Nonthaburi 11000, Thailand.
Onpawee SagarasaeraneeDepartment of Livestock Development, Ministry of Agriculture, Ratchathewi, Bangok 10400, Thailand.
Paisin LekcharoenFaculty of Veterinary Science, Chulalongkorn University, 39 Henri-Dunant Rd., Wangmai, Pathumwan, Bangkok 10330, Thailand.ORCID 0000-0003-3228-9542
Porathip TrinusonDepartment of Livestock Development, Ministry of Agriculture, Ratchathewi, Bangok 10400, Thailand.
Suwicha KasemsuwanFaculty of Veterinary Medicine, Kasetsart University, Kamphaeng Saen 73140, Thailand.ORCID 0000-0001-7462-6514
Kasetsart University · THChulalongkorn University · THDepartment of Livestock Development · THMinistry of Public Health · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Background: Thailand has made significant progress in reducing the number of human and animal rabies cases. However, control and elimination of the last remaining pockets of dog-mediated rabies have shown to be burdensome, predominantly as a result of the large numbers of free-roaming dogs without an owner that cannot be restrained without special efforts and therefore remain unvaccinated. To reach these dogs, the feasibility, and benefits of oral rabies vaccination (ORV) as a complementary tool has been examined under field conditions. (2) Methods: ORV of dogs was tested in five study areas of four provinces in Thailand. In these areas, sites with free-roaming dogs were identified with the support of local municipal workers and dog caretakers. ORV teams visited each of five study areas and distributed rabies vaccine (SPBN GASGAS) in three bait formats that were offered to the dogs using a hand-out and retrieval model. The three bait types tested included: egg-flavored baits, egg-flavored baits pasted with commercially available cat liquid snack, and boiled-intestine baits. A dog offered a vaccine bait was considered vaccinated when the discarded sachet was perforated or if a dog chewed vaccine bait at least 5 times before it swallowed the bait, including the sachet. (3) Results: A total of 2444 free-roaming dogs considered inaccessible for parenteral vaccination were identified at 338 sites. As not all dogs were approachable, 79.0% were offered a bait; of these dogs, 91.6% accepted the bait and subsequently 83.0% were considered successfully vaccinated. (4) Conclusion: Overall, 65.6% of the free-roaming dogs at these sites were successfully vaccinated by the oral route. Such a significant increase of the vaccination coverage of the free-roaming dog population could interrupt the rabies transmission cycle and offers a unique opportunity to reach the goal to eliminate dog-mediated human rabies in Thailand by 2030.

Indexed as

Administration, OralAnimalsAnimals, WildDisease EradicationDogsFemaleMaleRabiesRabies VaccinesVaccinationRabies Vaccinesdogoral vaccinationrabiesThailand

Identifiers

PMID33805404
PMCPMC8065424
OpenAlexW3146024756

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.